Registration Dossier
Registration Dossier
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EC number: 204-673-3 | CAS number: 124-04-9
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1970
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study is poorly documented, low number of animals, limited histopathology, nose as target organ not examined, MMAD not specified, purity not specified
Data source
Reference
- Reference Type:
- publication
- Title:
- The subacute inhalation toxicity of 109 industrial chemicals.
- Author:
- Gage JC
- Year:
- 1 970
- Bibliographic source:
- Brit. J. Industr. Med. 27, 1-18.
Materials and methods
- Principles of method if other than guideline:
- Two female and two male rats were maintained in the exposure chamber for 6 hours. Body weight and clinical behaviour was recorded every day. Urine was collected overnight after the last exposure day for biochemical testing. On the following day rats were anaesthetized, partially exsanguinated by heart puncture for hematological
tests and organs were grossly examined. Histopathology: lung, liver, kidneys, spleen, adrenals, and occasionally heart,
jejunum, ileum, and thymus. Test atmosphere was generated by injecting the powdered solid into a metered
air stream, MMAD not specified. - GLP compliance:
- no
Test material
- Reference substance name:
- Adipic acid
- EC Number:
- 204-673-3
- EC Name:
- Adipic acid
- Cas Number:
- 124-04-9
- Molecular formula:
- C6H10O4
- IUPAC Name:
- adipic acid
- Details on test material:
- IUCLID4 Test substance: purity not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderley Park
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 6 h
- Frequency of treatment:
- 15 applications
Doses / concentrations
- Remarks:
- Doses / Concentrations:
dust 126 mg/m3
Basis:
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: no data
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 126
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: No signs of toxicity were observed. Blood tests were normal and no pathological changes were reported at necropsy.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
No signs of toxicity were observed. Blood tests were normal
and no pathological changes were reported at necropsy.
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