Registration Dossier
Registration Dossier
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EC number: 203-835-0 | CAS number: 111-11-5
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (28 d and 56 d) >= 1000 mg/kg dw for Eisenia fetida (OECD 222)
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity of methyl octanoate(CAS No. 111-11-5) to soil macroorganisms are available. Therefore, data from a structurally related category member (methyl laurate (CAS No. 111-82-0) are used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Both substances are fatty esters esterified with methanol, differing only in the C-chain length of the fatty acid component: C8 (CAS No. 111-11-5) and C12 (CAS No. 111-82-0) respectively. Methyl laurate (CAS No. 111-82-0) exhibits the highest toxicity to aquatic organisms (Daphnia and algae) throughout the whole SCAE Me category, with EC50 and NOEC values < 1 mg/L. On the other hand, the results from the acute tests conducted on methyl octanoate (CAS No. 111-11-5) showed a lower toxicity to aquatic invertebrates and algae (EC50 > 1 mg/L). Therefore, methyl laurate is used as worst-case read across substance in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5.
The toxicity of methyl laurate (CAS No. 111-82-0) to earthworms was evaluated by Winkelmann (2013) in a test according to OECD 222, under GLP conditions. Eisenia fetida was exposed to the test substance for 56 days at a concentration of 1000 mg/kg dw (limit test). Mortality and growth were evaluated after 28 days whereas reproduction was evaluated after 56 days. After the exposure period, no effects on earthworm’s survival, reproduction or growth were observed, leading to a NOEC >= 1000 mg/kg dw.
Based on the results obtained for the structurally related category member (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5), it can be concluded thatmethyl octanoate(CAS No. 111-11-5) will not exhibit toxicity to soil macroorganisms.
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