Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endocrine disrupter testing in aquatic vertebrates – in vivo

Some information in this page has been claimed confidential.

Administrative data

fish life cycle: reproduction, (sub)lethal effects
OECD TG 234 (Fish Sexual Development Test)
Data waiving:
other justification
Justification for data waiving:

Data source

Materials and methods

Test guideline
according to guideline
OECD TG 234 (Fish Sexual Development Test)
Version / remarks:
As per the requirements of SEV-D-2114458054-52-01/F this study is currently in progress, and due to be reported November 2021. A full explanation from the relevant CRO is appended below for information as to the reason for the delay. The dossier will be updated as soon as possible after receipt of the study report.

Test material

Constituent 1
Details on test material:
- Name of test material (as cited in study report): Lowinox® TBM6
- Chemical name: 6,6’–di-tert-butyl-4,4’–thiodi-m-cresol
- Molecular formula: C22H30O2S
- Molecular weight: 358.54
- Substance type: White crystalline fine powder
- Physical state: solid
- Analytical purity: Minimum 98%
- Lot/batch No.: C029K1451
- Expiration date of the lot/batch: 20 october 2014
- Stability under test conditions: Stable
- Storage condition of test material: At room temperature in the dark

Test organisms

Aquatic vertebrate type:
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Results and discussion

Applicant's summary and conclusion