Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation, other
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Title:
DEREK NEXUS
Year:
2023
Bibliographic source:
DEREK (Version 6.2.1, Knowledge Base 2022 2.0)

Materials and methods

Test guideline
Guideline:
other: REACH Guidance on QSARs R.6
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
9-Butoxy-9-oxononanoic acid and dibutyl azelaate and butyl palmitate and butyl stearate and butyl (9 or 10)- oxooctadecanoate
EC Number:
941-798-9
IUPAC Name:
9-Butoxy-9-oxononanoic acid and dibutyl azelaate and butyl palmitate and butyl stearate and butyl (9 or 10)- oxooctadecanoate
Specific details on test material used for the study:
The SMILE of each identified component of the UVCB substance was used as input for the model.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks on result:
no indication of irritation
Remarks:
No alert predicted by the software Derek Nexus.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
No alert for eye irritation/corrosion was found by the software Derek Nexus .