Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

A bibliographic researches and in silico evaluations have been performed to characterize the toxicological profile of the UVCB substance.


Each component has been evaluated. When sufficient information on the components were not found with the literature research, the component has been evaluated by in silico methods.

Link to relevant study records
Reference
Endpoint:
in vitro gene mutation study in bacteria
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Guideline:
other: REACH Guidance on QSARs R.6
GLP compliance:
no
Specific details on test material used for the study:
The SMILE of each identified component of the UVCB substance was used as input for the model.
Species / strain:
bacteria, other: QSAR prediction in bacterium
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not determined
Conclusions:
Mutagenicity in vitro in bacterium is INACTIVE. No misclassified or unclassified features.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Justification for classification or non-classification