Registration Dossier
Registration Dossier
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EC number: 211-219-8 | CAS number: 634-93-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- skin irritation and sensitization study
- Author:
- NTRL Report
- Year:
- 1 984
- Bibliographic source:
- NTRL Report; 04/05/1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The skin irritation study of test chemical 2,4,6-trichloroaniline (CAS No: 634-93-5) was conducted on guinea pigs to observe its irritation efficacy.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4,6-trichloroaniline
- EC Number:
- 211-219-8
- EC Name:
- 2,4,6-trichloroaniline
- Cas Number:
- 634-93-5
- Molecular formula:
- C6H4Cl3N
- IUPAC Name:
- 2,4,6-trichloroaniline
- Test material form:
- solid
- Details on test material:
- -Name of the test material: 2,4,6-trichloroaniline
- Molecular formula: C6H4Cl3N
- Molecular weight: 196.464 g/mol
- Smiles notation: Nc1c(Cl)cc(Cl)cc1Cl
- InChl : 1/C6H4Cl3N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2
-Substance type: Organic
-Physical state: solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2,4,6-trichloroaniline
- Molecular formula: C6-H4-Cl3-N
- Molecular weight: 196.464 g/mol
- Smiles notation: c1(c(cc(Cl)cc1Cl)Cl)N
- InChl (if other than submission substance): 1S/C6H4Cl3N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2
- Substance type: organic
- Physical state: Solid
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Test system
- Type of coverage:
- occlusive
- Controls:
- not specified
- Amount / concentration applied:
- Not specified
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- Not specified
- Details on study design:
- Not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- slight irritation was observed in treated guinea pigs.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test material 2,4,6-trichloroaniline (CAS No: 634-93-5) was considered to be irritating to skin of guinea pigs.
- Executive summary:
The skin irritation study of test chemical 2,4,6-trichloroaniline (CAS No: 634-93-5) was conducted on guinea pigs to observe its irritation efficacy.
When the chemical was applied on skin of guinea pigs for 24 hours, slight irritation was observed in treated guinea pigs.
Hence the test chemical 2,4,6-trichloroaniline (CAS No: 634-93-5) was considered to be irritating to the skin of guinea pigs.
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