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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Only study summary available

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
lower animal number, abraded and non abraded skin
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-bis[(vinyloxy)methyl]cyclohexane
EC Number:
413-370-7
EC Name:
1,4-bis[(vinyloxy)methyl]cyclohexane
Cas Number:
17351-75-6
Molecular formula:
C12 H20 O2
IUPAC Name:
(1r,4r)-1,4-bis[(ethenyloxy)methyl]cyclohexane; (1s,4s)-1,4-bis[(ethenyloxy)methyl]cyclohexane
Details on test material:
- Name of test material (as cited in study report): divinyl ether of 1,4 cyclohexane, dimethanol
- Physical state: liquid
- desity: 0,96 g/ml

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: CAMM Research (Wayne, NJ, USA)
- Weight at study initiation: 2,48 - 2,75 kg

- Housing: single
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18,3 -23.9 °C (65-75 °F)
- Photoperiod (hrs dark / hrs light): 12 h

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: mid-dorsal area
- Type of wrap if used: J&J gauze sponge, J&J Dermicel hypo-allergenic cloth tape

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
Doses:
2000 mg/kg
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations wer 1, 3, 6 h post application and once daily afterwards
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Statistics:
none

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
No mortality was observed
Clinical signs:
other: No substance related symptoms were observed.
Gross pathology:
No gross internal changes were observed
Other findings:
Skin on the test site appears slightly reddend and scaling was noted.

Applicant's summary and conclusion

Executive summary:

The dermal acute toxicity study is reliable with restriction mainly to sight diviations from the OECD Guideline 402. 3 male and female rabbits recieved a limit dose of 2000 mg/kg on abraded and non abraded dorsal skin. No mortality (LD50 > 2000 mg/kg) and no clinical symptoms were observed. Necropsy reveald no gross findings. Beyond this sight reddening and scaling were observed at application site.

Conclusion

Dimethanol divinyl 1,4-cyclohexane is practically non-toxic after skin contact.