Ethanone, 1,2-diphenyl-, oxime

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

26 November 1997 - 13 May 1999

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Performed in a GLP laboratory in accordance with EPA test guidelines. No deviations were noted.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EPA OTS 798.1175 (Acute Oral Toxicity)

Deviations:

not specified

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

(Z)-N-(1,2-diphenylethylidene)hydroxylamine

EC Number:

811-357-4

Cas Number:

952-06-7

Molecular formula:

C14 H13 N O

IUPAC Name:

(Z)-N-(1,2-diphenylethylidene)hydroxylamine

Details on test material:

white powder

Test animals

Species:

rat

Strain:

Crj: CD(SD)

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Laboratories Inc.
- Age at study initiation: Young adult
- Weight at study initiation: 200 to 300 g
- Fasting period before study: 17 to 20 hours before test initiation
- Housing: Separated by sex and group housed in suspended, stainless steel cages
- Diet (e.g. ad libitum): Rodent Diet #8604 (Harlan Teklad) ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: 7 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18° to 26°C,
- Humidity (%): 50% ±20%
- Photoperiod (hrs dark / hrs light): 12-hour light/12-hour dark cycle

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 0.25 g/ml
- Amount of vehicle (if gavage): 20ml/kg

MAXIMUM DOSE VOLUME APPLIED: 5,000 mg/kg body weight

Doses:

5,000 mg/kg body weight

No. of animals per sex per dose:

five males and five females.

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 2.5 and 4 hours on day one followed by daily observations.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality was observed during the study. The estimated oral LD50 values for male and female rats were determined to be greater than 5,000 mg/kg of body weight.

Clinical signs:

other: No animals exhibited clinical signs throughout the study with the exception of one female (C22565) which exhibited staggered gait on the day of treatment (possibly test material-related).

Gross pathology:

There were no lesions observed at the gross necropsy examinations at termination.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: not specified

Conclusions:

The acute oral toxicity of SC-66276 was evaluated in male and female rats when
administered as a single gavage dose at a level of 5,000 mg/kg of body weight. No
mortality was observed during the study. The estimated oral Ll);0 values for male and
female rats were determined to be greater than 5,000 mg/kg. No animals exhibited
clinical signs throughout the study with the exception of one female (C22565) which
exhibited staggered gait on the day of treatment (possibly test material-related). All
animals exhibited body weight gain during the study. The gross necropsy examinations at
termination did not reveal any visible lesions.