Registration Dossier
Registration Dossier
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EC number: 208-395-3 | CAS number: 526-75-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from Authorative database
Data source
Reference
- Reference Type:
- other: Authorative database
- Title:
- RTECS® Registry of Toxic Effects of Chemical Substances: 2,3Xylenol
- Author:
- RTECS
- Year:
- 2 016
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 205, 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- The acute oral toxicity study of 2, 3-Dimethylphenol in rat
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 2,3-xylenol
- EC Number:
- 208-395-3
- EC Name:
- 2,3-xylenol
- Cas Number:
- 526-75-0
- Molecular formula:
- C8H10O
- IUPAC Name:
- 2,3-xylenol
- Details on test material:
- - Name of test material (as cited in study report): 2,3-xylenol
- Molecular formula (if other than submission substance): C8H10O
- Molecular weight (if other than submission substance): 122.16 g/mole
- Substance type: Organic
- Physical state: Solid
- Purity: No data available
- Impurities (identity and concentrations): No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2,3-xylenol
- Molecular formula (if other than submission substance): C8H10O
- Molecular weight (if other than submission substance): 122.16 g/mol
- Substance type: Organic
- Physical state: Solid
- Purity: No data available
- Impurities (identity and concentrations): No data available
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 562 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 562 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 was considered to be 562 mg/kg bw whe rats were treated with 2,3-dimethylphenol orally.
- Executive summary:
In a acute oral toxicity study, rat were treated with 2,3-dimethylphenol orally. 50 % mortality were observed in treated rat at 562 mg/kg bw. Therefore, LD50 was considered to be 562 mg/kg bw whe rats were treated with 2,3-dimethylphenol orally.
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