Trichloroacetaldehyde

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authoritative database.

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Eye irritation for CAS 71-55-6 (1,1,1-trichloroethane)

Author:

INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY (IPCS)

Year:

1990

Bibliographic source:

ENVIRONMENTAL HEALTH CRITERIA 136; INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY (IPCS); 1990

Reference 2

Reference Type:

secondary source

Title:

OECD HPV Chemical Programme, SIDS Dossier approved at SIAM 28

Author:

Epona Associates, LLC

Year:

2009

Bibliographic source:

OECD HPV Chemical Programme, SIDS Dossier approved at SIAM 28 (15-17 April 2009)

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

An eye irritation study of the given test chemical was conducted in rabbits to observe its irritation potential.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,1,1-trichloroethane

Cas Number:

71-55-6

Molecular formula:

C2H3Cl3

IUPAC Name:

1,1,1-trichloroethane

Test material form:

liquid

Details on test material:

- Name of test material (as cited in study report): Methylchloroform
- Molecular formula: C2H3Cl3
- Molecular weight: 133.405 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: C(C)(Cl)(Cl)Cl
- InChl: 1S/C2H3Cl3/c1-2(3,4)5/h1H3

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

not specified

Test system

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

Amount : 100 μl

Duration of treatment / exposure:

72 hours

Observation period (in vivo):

7 days

Duration of post- treatment incubation (in vitro):

not specified

Number of animals or in vitro replicates:

not specified

Details on study design:

TEST SITE
- Area of exposure: two drops of liquid onto the right eyeball was installed in rabbit’s eye.

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

7 d

Reversibility:

not specified

Remarks on result:

positive indication of irritation

Remarks:

Slight –moderately Irritating

Irritant / corrosive response data:

Slight to moderate pain and slight conjunctival irritation, but no corneal damage, was reported.

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritating to eyes) based on GHS criteria

Conclusions:

The test material was considered to be slightly irritating to the rabbits eye.

Executive summary:

An eye irritation study of the given test chemical was conducted in rabbits to observe its irritation efficacy. The inhibited and unhibited material was installed in rabbit's eye by introducing two drops of liquid onto the right eyeball. Visual observations of irritation and corneal injury (both internal and external) were made upon the treated eye at the following times after treatment: three minutes, one hour, and one, two, and seven days. A 5% water solution of fluorescein dye was used to stain and render visible the external injury of the cornea in all observations after the first (three minutes). One application of uninhibited or inhibited test chemical caused slight to moderate pain, slight conjunctival irritation but essentially no corneal damage. On the basis of observed effects, the given test chemical can be considered as slightly irritating to the eye of rabbits.