Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source.

Data source

Reference
Reference Type:
secondary source
Title:
Skin sensitization test of TRICHLOROACETALDEHYDE
Author:
E. I. DUPONT DE NEMOURS
Year:
1992
Bibliographic source:
E. I. DUPONT DE NEMOURS, 10/15/1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin sensitization test was carried out to study the sensitization potential in the given test chemical.
GLP compliance:
no
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroacetaldehyde
EC Number:
200-911-5
EC Name:
Trichloroacetaldehyde
Cas Number:
75-87-6
Molecular formula:
C2HCl3O
IUPAC Name:
2,2,2-trichloroacetaldehyde
Constituent 2
Reference substance name:
Chloral
IUPAC Name:
Chloral
Details on test material:
- Name of test material: Chloral
- Molecular formula: C2-H-Cl3-O
- Molecular weight: 147.3879 g/mol
- Substance type: Organic
- Physical state: liquid

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Study design: in vivo (non-LLNA)

Induction
Route:
other: not specified
Vehicle:
other: not specified
Concentration / amount:
not specified
Day(s)/duration:
not specified
Adequacy of induction:
not specified
Challenge
Route:
other: not specified
Vehicle:
not specified
Concentration / amount:
not specified
Day(s)/duration:
not specified
Adequacy of challenge:
not specified
No. of animals per dose:
not specified
Details on study design:
not specified
Challenge controls:
not specified
Positive control substance(s):
not specified

Results and discussion

Positive control results:
not specified

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
2%
No. with + reactions:
0
Clinical observations:
Allergic contact dermatitis did not developed.not sensitizing
Remarks on result:
no indication of skin sensitisation

Any other information on results incl. tables

Other Details not known

Applicant's summary and conclusion

Interpretation of results:
other: not sensitising
Conclusions:
The given test chemical is not sensitizing to the skin of guinea pig.
Executive summary:

Skin sensitization study was conducted for the given test chemical. A test for sensitization revealed that allergic contact dermatitis did not develop. A 2% solution was not irritating to the skin of guinea pig. It can be concluded that the test chemical is not sensitizing.