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Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: This study meets generally accepted scientific principles, so it is acceptable for assessment. No data on GLP.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1987
Report date:
1986

Materials and methods

Principles of method if other than guideline:
The sex related response to zinc acetate was investigated in mice. Male and female adult ICR-mice were administered single intraperitoneal injections of test substance. The median lethal dose (LD50) was calculated 1, 3, 5, 7, and 14 days following administration.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Zinc di(acetate)
EC Number:
209-170-2
EC Name:
Zinc di(acetate)
Cas Number:
557-34-6
Molecular formula:
C2H4O2.1/2Zn
IUPAC Name:
zinc diacetate
Details on test material:
- Name of test material (as cited in study report): Zinc acetate, ZnAc2

Test animals

Species:
mouse
Strain:
ICR
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 10-20 weeks
- Weight at study initiation: 32-35 g
- Diet (e.g. ad libitum): Freely available all time.
- Water (e.g. ad libitum): Freely available all time.

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Details on exposure:
Stock solution of ZnAc2 was prepared the day of injection (day 0) with serial dilutions made and used for the injection series.
Doses:
35, 42, 50, and 60 mg/kg bw.
No. of animals per sex per dose:
10 male and 10 female animals per dose group
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
42 mg/kg bw
Based on:
test mat.
95% CL:
37.5 - 47.1
Sex:
female
Dose descriptor:
LD50
Effect level:
42 mg/kg bw
Based on:
test mat.
95% CL:
38.2 - 46.2
Mortality:
Nearly all deaths occurred by day seven, with few deaths occurring between 7 and 14 days.
Gross pathology:
Autopsies revealed extreme vasodilation of abdominal vessels and cardiac arrest in diastole.

Any other information on results incl. tables

Ther LD50 for male and female mice treated with Zinc Acetate was 42.0 mg/kg bw.

Applicant's summary and conclusion

Conclusions:
Ther LD50 for male and female mice treated with Zinc Acetate was 42.0 mg/kg bw.
Executive summary:

The sex related response to zinc acetate was investigated in mice. Male and female adult ICR-mice were administered single intraperitoneal injections of test substance. The median lethal dose (LD50) was calculated 1, 3, 5, 7, and 14 days following administration.

Nearly all deaths occurred by day seven, with few deaths occurring between 7 and 14 days.

Ther LD50 for male and female mice treated with Zinc Acetate was 42.0 mg/kg bw.