Sodium N-(hydroxymethyl)glycinate

Toxicity to birds

Administrative data

Endpoint:

short-term toxicity to birds: acute oral toxicity test

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study according to a FIFRA guideline.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1991

Report date:

1991

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EPA OPP 71-1 (Avian Acute Oral Toxicity Test)

Deviations:

no

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Sodium N-(hydroxymethyl)glycinate

EC Number:

274-357-8

EC Name:

Sodium N-(hydroxymethyl)glycinate

Cas Number:

70161-44-3

Molecular formula:

C3H7NO3.Na

IUPAC Name:

sodium N-(hydroxymethyl)glycinate

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Suttocide A (Powder}; Lot No. J15-150D with a purity of 97%.

Dose method:

other: a single dose of the test substance in diluent was orally intubated directly into the crop or proventriculus of each bird using a stainless steel cannula.

Analytical monitoring:

yes

Vehicle:

yes

Test organisms

Test organisms (species):

Colinus virginianus

Study design

Limit test:

no

Remarks:

1. Acclimation - 16 days. 2. Fasting - At least 15 hours prior to dosing. 3. Dosing - Experimental Start Date - October 12, 1990. 4. Post-dosing observation - 14 days.

No. of animals per sex per dose and/or stage:

5

Control animals:

yes

Results and discussion

Effect levels

Duration (if not single dose):

14 d

Dose descriptor:

LD50

Effect level:

> 2 250 mg/kg bw

Conc. / dose based on:

test mat.

Basis for effect:

mortality

Any other information on results incl. tables

There were no mortalities at the 486, 810 or 1350 mg/kg dosages. There was a single, incidental mortality at 292 mg/kg. There was 40% mortality (4 of 10) at 2250 mg/kg. Treatment related effectswere seen at 810 mg/kg and higher dosages. These effects were reversible even at the highest dosage. Signs of toxicity typical of intoxication with Suttocide A included ruffled appearance, lethargy, reduced reaction to external stimuli (sound and movement), lower limb weakness, depression, wing droop and coma.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The acute oral LD5O value for northern bobwhite exposed to Suttocide A as a single oral dosage was determined to be greater than 2250 mg/kg, the highest dosage tested. The no mortality level was 1350 mg/kg. The no observed effect level was 486 mg/kg based on signs of toxicity and a loss in body weight at 810 mg/kg.