Talc (Mg3H2(SiO3)4)

GHS

General Information

Name:

Talc (Mg3H2(SiO3)4)

Not classified

Implementation:

EU

Remarks:

There are no indications that orally or inhalation administered talc is absorbed by rats, mice, hamsters or guinea pigs. 

Talc administered into the pleural space of rats is distributed systemically throughout the body.

Talc elimination of radioactivity was determined in the urine and faeces and thereforeTalc (Mg3H2(SiO3)4) has no bioaccumulation potential.

 

Exposure to talc does not lead to any relevant dermal absorption. Therefore designation with an “H” is not necessary.

There is no information that would justify a designation of talc with “Sa” or “Sh” (for substances which cause sensitization).

Nor can a classification of talc into a category for germ cell mutagens be justified on the basis of the available data.

There was no evidence of carcinogenic activity in male or female B6C3F1 mice.

A bioassay using rats was performed by the NTP to determine the carcinogenic potential of non-asbestiform, cosmetic-grade micro-talc following exposure by inhalation, and it was concluded there was some evidence of carcinogenic activity in male F344/rats, and clear evidence of carcinogenic activity in female F344/N rats. The rats were exposed to 6 mg/m3 (MMAD 2.7 ± 1.9 μm) or 18 mg/m3 (MMAD 3.2 ± 1.9 μm) talc for 6 h/day, 5 days/wk, for 113wks (males) or 122 wks (females).Concerns have been raised about this study, including concerns that micronized talc having a significantly smaller particle size distribution than cosmetic talc was used, aerosol concentrations were not properly controlled, proper procedures for dose selection were not followed resulting in the MTD being exceeded at both concentrations tested, and particle overload in the lungs was most likely the cause of the adverse effects reported.

The talc used in the this study was a commercially available microtalc whose dimensions of < 10 µm were distinctly finer than the cosmetic powder normally used.

Therefore, the study is not conclusive with regard to a possible carcinogenicity of large talc platelets or talc fibres.

There are conclusive but not suffcient data for the classification of substance Talc (Mg3H2(SiO3)4) with regard to carcinogenicity.

 Not classifiable as a human carcinogen. /Talc containing no asbestos fibers/
[American Conference of Governmental Industrial Hygienists TLVs and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices.,, 2008, p. 54

It is concluded that talc not containing asbestos or asbestiform fibres is safe in the present practices of use.

Related composition

Related composition:

Talc (Mg3H2(SiO3)4)

Talc (Mg3H2(SiO3)4)

Classification

Physical hazards

Explosives

Reason for no classification:

data conclusive but not sufficient for classification

Flammable gases and chemically unstable gases

Reason for no classification:

data conclusive but not sufficient for classification

Aerosols

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data conclusive but not sufficient for classification

Gases under pressure

Reason for no classification:

data conclusive but not sufficient for classification

Flammable liquids

Reason for no classification:

data conclusive but not sufficient for classification

Flammable solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-reactive substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric liquids

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-heating substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising liquids

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising solids

Reason for no classification:

data conclusive but not sufficient for classification

Organic peroxides

Reason for no classification:

data conclusive but not sufficient for classification

Corrosive to metals

Reason for no classification:

data conclusive but not sufficient for classification

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - dermal

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - inhalation

Reason for no classification:

data conclusive but not sufficient for classification

Skin corrosion / irritation

Reason for no classification:

data conclusive but not sufficient for classification

Serious eye damage / eye irritation

Reason for no classification:

data conclusive but not sufficient for classification

Respiratory sensitisation

Reason for no classification:

data conclusive but not sufficient for classification

Skin sensitisation

Reason for no classification:

data conclusive but not sufficient for classification

Aspiration hazard

Reason for no classification:

data conclusive but not sufficient for classification

Reproductive toxicity

Reason for no classification:

data conclusive but not sufficient for classification

Effects on or via lactation

Reason for no classification:

data conclusive but not sufficient for classification

Germ cell mutagenicity

Reason for no classification:

data conclusive but not sufficient for classification

Carcinogenicity

Reason for no classification:

data conclusive but not sufficient for classification

1. Specific target organ toxicity - single (STOT-SE)

Reason for no classification:

data conclusive but not sufficient for classification

1. Specific target organ toxicity - repeated (STOT-RE)

Reason for no classification:

data conclusive but not sufficient for classification

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Reason for no classification:

data conclusive but not sufficient for classification

Hazardous to the aquatic environment (long-term)

Reason for no classification:

data conclusive but not sufficient for classification

Hazardous to the ozone layer

Reason for no classification:

data conclusive but not sufficient for classification

Labelling

Signal word:

No signal word

Precautionary statements

P101: If medical advice is needed, have product container or label at hand.

P102: Keep out of reach of children.

P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.