Registration Dossier
Registration Dossier
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EC number: 203-397-0 | CAS number: 106-43-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: females only, no GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
- Principles of method if other than guideline:
- Single application of 5000 mg/kg bw of the shaved back of 6 female wistar rats, covered by alu foil and elastic bandage for 24 hours. Afterwards the treatment area was carefully cleaned with warm water. Post exposure observation time was 14 days. At termination rats were sacrificed and pathologically evaluated.
- GLP compliance:
- no
- Test type:
- other: limit test - application 5000 mg/kg bw
- Limit test:
- yes
Test material
- Reference substance name:
- 4-chlorotoluene
- EC Number:
- 203-397-0
- EC Name:
- 4-chlorotoluene
- Cas Number:
- 106-43-4
- Molecular formula:
- C7H7Cl
- IUPAC Name:
- 4-chlorotoluene
- Details on test material:
- p-chlorotoluene (no data on purity)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- undiluted testsubstance: 5000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
Any other information on results incl. tables
reduced food consumption during the duration of exposure
(24 hours) and little weight loss immediately after application were observable; no deaths occurred; no other signs of intoxication were observed; pathological evaluation revealed no finding.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Executive summary:
method: Single application of 5000 mg/kg bw of the shaved back of 6 female wistar rats, covered by alu foil and elastic bandage for 24 hours. Afterwards the treatment area was carefully cleaned with warm water. Post exposure observation time was 14 days. At termination rats were sacrificed and pathologically evaluated.
result: LD50 > 5000 mg/kg bw; all animals survived, no signs of intoxication observed
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