Registration Dossier
Registration Dossier
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EC number: 203-397-0 | CAS number: 106-43-4
Endpoint summary
Administrative data
Description of key information
In a subacute study 5 male and female Wistar rats each received for 29 days a dose of 0, 50, 200, or 800 mg/kg bw p-chlorotoluene per gavage. Mortality, clinical signs, body weight, clinical chemistry, hematology and urinalysis were performed including gross pathology and histopathology after the termination of the study.
No studies are available for repeated dose dermal and inhalative toxicity
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 200 mg/kg bw/day
Additional information
A NOAEL of 200 mg/kg bw/days was found in the subacute oral gavage study in rats. General condition, appearance, food and water intake, growth and mortality was not influenced by treatment up to and including 200 mg/kg bw/day.
With 800 mg/kg bw/d some animals showed increased salivation. Food intake and growth inmale animals were retarded and a slight elevation in mortality was observed. The hematological examinations revealed for all applied doses no evidence for adverserse effects.With 800 mg/kg bw/day one female animal showed focal infiltration and vacuoles in the hepatocytes. No evidence was seen for adverse effects of the liver up to an including doses of 200 mg/kg bw/d. Hematological, clinical chemistry and pathological examinations revealed no adverse effects on kidneys and all other organs examined.
Justification for classification or non-classification
Due to the results of the subacute gavage study in rats a classification is not justified.
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