Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study with limited documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Principles of method if other than guideline:
Acute dermal toxicity test in rabbits
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
(2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran
EC Number:
221-217-9
EC Name:
(2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran
Cas Number:
3033-23-6
Molecular formula:
C10H18O
IUPAC Name:
(2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran
Details on test material:
- Name of test material (as cited in study report): Rose oxide levo
- Other: stereoisomer of rose oxide
- Lot/batch No.: 73-222
no further data given

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
3 (sex not specified)
Control animals:
other: not applicable
Details on study design:
- Duration of observation period following administration: 14 days
no further data given

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality observed
Clinical signs:
other: Slight erythema in 2/3 animals Moderate erythema in 1/3 animals Moderate edema in 3/3 animals
Gross pathology:
No data

Applicant's summary and conclusion