2-[3-(4-propyl-heptyl)-morpholin-4-yl]-ethanol hydrochloride

Oxidising properties

Link to relevant study record(s)

Reference

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

August 10, 2016 - October 21, 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.17 (Oxidising Properties (Solids))

Deviations:

no

Principles of method if other than guideline:

Method Description
The reference material, barium nitrate, with a particle size lower than 0.125 mm (120 mesh), was dried at 105°C overnight.
The cellulose, with a declared particle size of ca 50 micrograms, was dried at 105°C overnight.
Dried cellulose and barium nitrate were cooled in a desiccator and stored in glass bottles with screw caps.
The entire amount of the test item was passed through a 0.125 mm sieve and was dried overnight at 105°C.

The test item and reference substance were mixed with the cellulose in various ratios ranging from 10% to 90% w/w of cellulose in 10% increments. For each mixture a pile was formed in a 250 mm long metal mould, consisting of a triangular cross-section with an inner height of 10 mm and an inner width of 20 mm. After dropping once the mould from a height of approx. 2 cm onto a solid surface, excess substance was removed. After removal of the lateral limitations a non-combustible, non-porous and low heat-conducting plate was placed on the top of the pile. Then the apparatus was inverted and the mould removed. Thereafter, one end of the mould was ignited with a Bunsen burner flame, and the time of reaction over a distance of 200 mm was recorded after the reaction zone had propagated an initial distance of 30 mm.
The burning rates were compared with the maximum burning rate of the reference mixture.

GLP compliance:

no

Specific details on test material used for the study:

Internal sample code: 2929564-001
Purity: 100.3% w/w
Batch number: 2510468

Contact with:

powdered cellulose

Duration of test (contact time):

ca. 8 h

Key result

Sample tested:

other: See details in "Any other infromtion on results"

Remarks:

See details in "Any other infromtion on results"

Parameter:

burning time of reaction over a distance of 200 mm

Result:

> 138 - < 168 s

Remarks on result:

other: "wick effect” was observed

Remarks:

"wick effect” was observed

Results and Conclusions

The barium nitrate reference substance was mixed with dried cellulose in various ratios and tested as described in the experimental section above.

Data and results of the different mixtures are reported in the following Table:

Barium nitrate / cellulose (% w/w)	Burning time over (sec)	Burning rate (mm/sec)
60 / 40	382	0.52
50 / 50	331	0.60
40 / 60	309	0.65
0 / 100	286	0.70

 

The maximum burning rate of the reference substance mixture was achieved with barium nitrate mixed with dried cellulose in the proportion 40 to 60 (w/w).

The test item was mixed with dried cellulose in various ratios and tested as described in the experimental section.

Data and results of the different mixtures are reported below:

Mixture	Test item / cellulose (% w/w)	Burning time over (sec)	Burning rate (mm/sec)
A	10 / 90	405	0.49
B	20 / 80	226	0.88
C	30 / 70	223	0.90
D	40 / 60	235	0.85
E	50 / 50	220	0.91
F	60 / 40	217	0.92
G	70 / 30	burning does not propagate	-
H	80 / 20	burning does not propagate	-
I	90 / 10	burning does not propagate	-

From these preliminary results, the test item could have oxidizing properties.

 

In order to investigate the possible false positive hypothesis, the tests with the four fastest mixtures (C, D, E and F) were repeated usingkieselguhr(diatomaceous earth) as an inert support instead of the combustible cellulose. If the test item is a true oxidizing substance, the burning rate would be slower as the test item has no material to oxidize.

 

The results obtained for the mixtures with kieselguhr are reported in Table below.

 

Test conducted using kieselguhr on the fastest mixtures

 

Mixture	Test Item / Kieselguhr (% w/w)	Burning time over (sec)	Burning rate (mm/sec)
C	30 / 70	burning does not propagate	-
D	40 / 60	burning does not propagate	-
E	50 / 50	168	1.19
F	60 / 40	138	1.45

 

 

The test repeated with the same ratios with the test item, but using kieselguhr as an inert support, showed burning rates for mixtures E and F faster than those observed using the combustible cellulose while for mixtures C and D the burning did not propagate.

The presence of the cellulose was, therefore, not important for the burning of mixtures.

Instead the “wick effect” was observed; i.e. the test item melted when the ignition source was applied and became flammable in the presence of the solid carrier.

Interpretation of results:

GHS criteria not met

Conclusions:

From the obtained experimental data according to the Oxidizing Properties (OJEC A.17) method, it can be concluded that the Delmopinolo HCl sample is a non-oxidizing substance.

Executive summary:

Delmopinolo HCl sample is a non-oxidizing substance.

Key value for chemical safety assessment

Oxidising properties:

non oxidising

Justification for classification or non-classification

From the obtained experimental data according to the Oxidizing Properties (OJEC A.17) method, it can be concluded that the Delmopinolo HCl sample is a non-oxidizing substance.