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EC number: 201-348-8 | CAS number: 81-42-5
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Biodegradability of test chemical 1,4-diamino-2,3-dichloroanthraquinone (CASno. 81-42-5) is predicted using OECD QSAR tool box v.3.3using log Kow as primary descriptor. The test chemical 1,4-diamino-2,3-dichloroanthraquinone undergoes 0.125 % degradation by taking BOD as parameter and microorganisms as inoculum in 28 days. Based on percent biodegradability of test chemical 1,4-diamino-2,3-dichloroanthraquinone it is concluded that this test chemical is not readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1,4-diamino-2,3-dichloroanthraquinone (CAS No. 81-42-5). If released in to the environment, 8.61 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of test chemical 2-methylanisole in sediment is estimated to be 541.66 days (13000 hrs). However, as the percentage release of test chemical into the sediment is less than 3 % (i.e, reported as 2.05 %), indicates that test chemical 1,4-diamino-2,3-dichloroanthraquinone is not persistent in sediment.
Biodegradation in soil:
The half-life period of test chemical 1,4-diamino-2,3-dichloroanthraquinone (CAS No.81-42-5) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 89.3 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 1,4-diamino-2,3-dichloroanthraquinone in soil is estimated to be 120 days (2880 hrs). Based on this half-life value of test chemical 1,4-diamino-2,3-dichloroanthraquinone, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
Additional information
Biodegradation in water:
Predicted data for target chemical 1,4-diamino-2,3-dichloroanthraquinone (CAS no. 81-42-5) and supporting weight of evidence studies for its read across chemicals with log Kow as primary descriptor were review for biodegradation endpoint which are summarized as below.
Biodegradability of test chemical 1,4-diamino-2,3-dichloroanthraquinone (CAS no. 81-42-5) is predicted using OECD QSAR tool box v.3.3using log Kow as primary descriptor. The test chemical 1,4-diamino-2,3-dichloroanthraquinone undergoes 0.125 % degradation by taking BOD as parameter and microorganisms as inoculum in 28 days. Based on percent biodegradability of test chemical 1,4-diamino-2,3-dichloroanthraquinone it is concluded that this test chemical is not readily biodegradable.
Another prediction done by using Estimation Programs Interface Suite (EPI suite, 2017) to estimate the biodegradation potential of the test compound 1,4-diamino-2,3-dichloroanthraquinone (CAS no. 81-42-5) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 1,4-diamino-2,3-dichloroanthraquinone is expected to be not readily biodegradable.
In a supporting weight of evidence study from authoritative database (J Check, 2017) the Biodegradation experiment was carried out for read across chemical 1-amino-2-bromo-4-hydroxy-9,10-dihydroanthracene-9,10-dione (CAS no.116-82-5) by taking activated sludge as inoculums at 30 mg/L concentration for 28 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by HPLC .The initial concentration of read across chemical was 100 mg/L. After 4 weeks of incubation percent biodegradation of read across chemical 1-amino-2-bromo-4-hydroxy-9,10-dihydroanthracene-9,10-dione was observed to be 1.0 % by BOD parameter 0.0 % by test material analysis by HPLC parameter.Therefore it is concluded that read across chemical 1-amino-2-bromo-4-hydroxy-9,10-dihydroanthracene-9,10-dione is not readily biodegradable.
In another supporting weight of evidence study from authoritative database (J Check, 2017) of read across chemical 2,2'-dichloro-4,4'-methylenedianiline (CAS no. 101-14-4) biodegradation test was carried out by taking activated sludge as inoculums at 30 mg/L concentration. Biodegradation was analyzed by using two parameters that are O2 consumption (BOD) and test material analysis by HPLC. The initial concentration of read across chemical was 100 mg/L and equipment used in study was of standard type. After four weeks (28 days) of incubation read across chemical 2,2'-dichloro-4,4'-methylenedianiline undergoes 0.0 % degradation by O2 consumption (BOD) parameter and 1.0 % degradation by test material analysis by HPLC parameter. Thus based on percent biodegradability it is concluded that read across chemical 2,2'-dichloro-4,4'-methylenedianiline is not readily biodegradable.
On the basisof above results for target chemical 1,4-diamino-2,3-dichloroanthraquinone (CAS no. 81-42-5) from OECD tool box v.3.3 and EPI suite and for its read across chemicals from authoritative database (J Check, 2017) the target chemical 1,4-diamino-2,3-dichloroanthraquinone is expected to be not readily biodegrdable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1,4-diamino-2,3-dichloroanthraquinone (CAS No. 81-42-5). If released in to the environment, 8.61 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of test chemical 2-methylanisole in sediment is estimated to be 541.66 days (13000 hrs). However, as the percentage release of test chemical into the sediment is less than 3 % (i.e, reported as 2.05 %), indicates that test chemical 1,4-diamino-2,3-dichloroanthraquinone is not persistent in sediment.
Biodegradation in soil:
The half-life period of test chemical 1,4-diamino-2,3-dichloroanthraquinone (CAS No.81-42-5) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 89.3 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 1,4-diamino-2,3-dichloroanthraquinone in soil is estimated to be 120 days (2880 hrs). Based on this half-life value of test chemical 1,4-diamino-2,3-dichloroanthraquinone, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
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