Registration Dossier
Registration Dossier
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EC number: 201-348-8 | CAS number: 81-42-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals and handbooks
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment of Disperse Violet 1
- Author:
- Cosmetic Ingredient Review Expert Panel
- Year:
- 1 991
- Bibliographic source:
- JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY, Volume 10, Number 1,pp 103-111, 1991
- Reference Type:
- review article or handbook
- Title:
- Eye Irritation test for Disperse Violet 1
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 012
- Bibliographic source:
- Sax's Handbook of Dangerous Industrial Materials,12th Edition, 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Draize method
- Principles of method if other than guideline:
- To assess the ocular irritation potential of Disperse Violet 1 in rabbits according to Draize method
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,4-diaminoanthraquinone
- EC Number:
- 204-922-6
- EC Name:
- 1,4-diaminoanthraquinone
- Cas Number:
- 128-95-0
- Molecular formula:
- C14H10N2O2
- IUPAC Name:
- 1,4-diamino-9,10-anthraquinone
- Test material form:
- solid
- Details on test material:
- Name of the test chemical:1,4-diamino-9,10-anthraquinone
Common Name: Disperse Violet 1
Molecular Formula: C14H10N2O2
Molecular Weigth: 238.245 g/mol
InChI: 1S/C14H10N2O2/c15-9-5-6-10(16)12-11(9)13(17)7-3-1-2-4-8(7)14(12)18/h1-6H,15-16H2
Substance Type: Organic
Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical:1,4-diamino-9,10-anthraquinone
Common Name: Disperse Violet 1
Molecular Formula: C14H10N2O2
Molecular Weigth: 238.245 g/mol
InChI: 1S/C14H10N2O2/c15-9-5-6-10(16)12-11(9)13(17)7-3-1-2-4-8(7)14(12)18/h1-6H,15-16H2
Substance Type: Organic
Physical State: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- number not specified
- Details on study design:
- TEST SITE
- Area of exposure: conjunctival sac
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Moderate irritation was observed
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Disperse Violet 1 was moderately irritating to rabbit eyes after 24 hours of exposure.
Hence,Disperse Violet 1can be considered to be an eye irritant. - Executive summary:
The ocular irritation potential of Disperse Violet 1 was assessed in rabbits according to Draize method.
500 mg of Disperse Violet 1 was instilled into the conjunctival sac of rabbits (number not specified) and the eyes were examined 24 hours later.Disperse Violet 1 was moderately irritating to rabbit eyes after 24 hours of exposure.
Hence, Disperse Violet 1can be considered to be an eye irritant.
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