Dioctyl sebacate

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

data is from authoritative database.

Qualifier:

according to guideline

Guideline:

other: refer principle below

Principles of method if other than guideline:

Biodegradation of test chemical 1,10-dioctyl decanedioate was analysed by BOD, and Test material analysis by GC parameter for 21 days by taking activated sludge as inoculums.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name (IUPAC): 1,10-dioctyl decanedioate
- Molecular formula: C26H50O4
- Molecular weight: 426.677 g/mol
- Smiles notation: C(=O)(OCCCCCCCC)CCCCCCCCC(=O)OCCCCCCCC
- InChl: 1S/C26H50O4/c1-3-5-7-9-15-19-23-29-25(27)21-17-13-11-12-14-18-22-26(28)30-24-20-16-10-8-6-4-2/h3-24H2,1-2H3
- Substance type: Organic
- Physical state: liquid (colourless to light yellow)

Oxygen conditions:

not specified

Inoculum or test system:

activated sludge (adaptation not specified)

Details on inoculum:

Concentration of activated sludge: 30 mg/L

Duration of test (contact time):

21 d

Initial conc.:

100 mg/L

Based on:

test mat.

Parameter followed for biodegradation estimation:

other:

Remarks:

BOD

Parameter followed for biodegradation estimation:

test mat. analysis

Remarks:

GC

Details on study design:

Standard type

Parameter:

other:

Remarks:

BOD

Value:

78.2

Sampling time:

21 d

Remarks on result:

other: other details not available

Parameter:

% degradation (test mat. analysis)

Remarks:

GC

Value:

100

Sampling time:

21 d

Remarks on result:

other: other details not available

Details on results:

Percent biodegradation of test chemical 1,10-dioctyl decanedioate was observed to be 78.2 % by BOD parameter 100 % by test material analysis by GC parameter in 21 days.

Validity criteria fulfilled:

not specified

Interpretation of results:

readily biodegradable

Conclusions:

Percent biodegradation of test chemical 1,10-dioctyl decanedioate was observed to be 78.2 % by BOD parameter 100 % by test material analysis by GC parameter in 21 days. Therefore it is concluded that test chemical 1,10-dioctyl decanedioate is readily biodegradable.

Executive summary:

The Biodegradation experiment was carried out of test chemical 1,10-dioctyl decanedioate (CAS no. 2432-87-3) by taking activated sludge as inoculums at 30 mg/L concentration for 21 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by GC .The initial concentration of test chemical was 100 mg/L. The study design was of standard type. After 3 weeks of incubation percent biodegradation of test chemical1,10-dioctyl decanedioate was observed to be 78.2 % by BOD parameter 100 % by test material analysis by GC parameter in 21 days.Therefore it is concluded that test chemical1,10-dioctyl decanedioate is readily biodegradable.

Description of key information

The Biodegradation experiment was carried out of test chemical 1,10-dioctyl decanedioate (CAS no. 2432-87-3) by taking activated sludge as inoculums at 30 mg/L concentration for 21 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by GC .The initial concentration of test chemical was 100 mg/L. The study design was of standard type. After 3 weeks of incubation percent biodegradation of test chemical1,10-dioctyl decanedioate was observed to be 78.2 % by BOD parameter 100 % by test material analysis by GC parameter in 21 days.Therefore it is concluded that test chemical 1,10-dioctyl decanedioate is readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:

readily biodegradable

Additional information

Experimental data and predicted data for the target compound1,10-dioctyl decanedioate (CAS no. 2432-87-3) and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:

In a first weight of evidence study the Biodegradation experiment was carried out of test chemical 1,10-dioctyl decanedioate (CAS no. 2432-87-3) by taking activated sludge as inoculums at 30 mg/L concentration for 21 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by GC . The initial concentration of test chemical was 100 mg/L. The study design was of standard type. After 3 weeks of incubation percent biodegradation of test chemical 1,10-dioctyl decanedioate was observed to be 78.2 % by BOD parameter 100 % by test material analysis by GC parameter in 21 days. Therefore it is concluded that test chemical 1,10-dioctyl decanedioate is readily biodegradable.

Next weight of evidence study was prediction in this the biodegradability of test chemical 1,10-dioctyl decanedioate (CAS no. 2432 -87 -3) was predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. The test chemical 1,10-dioctyl decanedioate showed 81.80 % biodegradation by considering BOD as parameter and microorganism as inoculum in 28 days. Therefore it is concluded that test chemical 1,10-dioctyl decanedioate is readily biodegradable.

Another prediction done by using Estimation Programs Interface Suite (EPI suite, 2017) to estimate the biodegradation potential of the test compound1,10-dioctyl decanedioate (CAS no. 2432-87-3) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 1,10-dioctyl decanedioate is expected to be readily biodegradable.

In a supporting weight of evidence study from authoritative database (J Check, 2017) the Biodegradation experiment was carried out of read across chemical 1,6-bis(2-ethylhexyl) hexanedioate (CAS no. 103-23-1)by taking activated sludge as inoculums at 30 mg/L concentration for 28 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by GC. The initial concentration of read across chemical was 100 mg/L. The study design was of standard type. After 4 weeks of incubation percent biodegradation of read across chemical1,6-bis(2-ethylhexyl) hexanedioate was observed to be 71 % by BOD parameter 85 % by test material analysis by GC parameter .Therefore it is concluded that read across chemical 1,6-bis(2-ethylhexyl) hexanedioate is readily biodegradable.

In another supporting weight of evidence study from authoritative database (J Check, 2017) Biodegradability of read across chemical didodecyl 3,3'-sulfanediyldipropanoate (CAS no. 123-28-4) was determined by taking activated sludge as inoculums at 30 mg/L concentration for 28 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by HPLC. The initial concentration of read across chemical was 100 mg/L and study design was of standard type. After 4 weeks of incubation Percent biodegradation of read across chemical didodecyl 3,3'-sulfanediyldipropanoate was observed to be 82 % by BOD parameter and 97% by test material analysis by HPLC parameter in 28 days. Therefore it is concluded that read across chemical didodecyl 3,3'-sulfanediyldipropanoate is readily biodegradable.

On the basis of results of above mentioned studies for target chemical1,10-dioctyl decanedioate (CAS no. 2432-87-3) (From J Check, OECD QSAR tool boxv3.3 and EPI suite) and supporting weight of evidence study ( from J Check, 2017). It is concluded that the test chemical1,10-dioctyl decanedioate (CAS no. 2432-87-3) can be expected to be readily biodegradable.