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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Several acute oral studies and a dermal toxicity study are available for 1,4-dihydroxyanthraquinone. No study is available for acute inhalation toxicity. This does not need to be conducted according REACH Annex VII column 2 because valid studies for acute oral and dermal toxicity are on hand.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
5 000 mg/kg bw
Quality of whole database:
The materials/methods and results are described in detail and are sufficient for evaluation.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 500 mg/kg bw
Quality of whole database:
The materials/methods and results are described in detail and are sufficient for evaluation.

Additional information

In 3 valid acute oral toxicity studies a LD50 > 5000 mg/kg bw was found. None of the animals died at a single oral dose of 5000 mg/kg bw. In the acute dermal toxicity study the highest applied dose was 2500 mg/kg bw. None of the animals died after application of 2500 mg 1,4-dhihydroxyanthraquinone.


Justification for classification or non-classification

In 3 valid acute oral toxicity studies a LD50 > 5000 mg/kg bw was found. None of the animals died at a single oral dose of 5000 mg/kg bw. In the acute dermal toxicity study the highest applied dose was 2500 mg/kg bw. None of the animals died after application of 2500 mg 1,4-dhihydroxyanthraquinone.

According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.