Registration Dossier
Registration Dossier
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EC number: 218-129-8 | CAS number: 2051-78-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Henry F. Smyth Jr., Charles P. Carpenter, Carrol S. Well, Urbano C. Pozzani & Jean A. Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 1962, 23:2, 95-107
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the eye irritation potential of vinyl propanoate in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Vinyl propionate
- EC Number:
- 203-293-5
- EC Name:
- Vinyl propionate
- Cas Number:
- 105-38-4
- Molecular formula:
- C5H8O2
- IUPAC Name:
- Ethenyl propanoate
- Test material form:
- liquid
- Details on test material:
- Name of the test chemical: Ethenyl propanoate
Common Name: Vinyl propanoate
Molecular Formula: C5H8O2
Molecular Weight: 100.116 g/mol
Substance Type: Organic
Physical State: Liquid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical: Ethenyl propanoate
Common Name: Vinyl propanoate
Molecular Formula: C5H8O2
Molecular Weight: 100.116 g/mol
Substance Type: Organic
Physical State: Liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- no data available
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- TEST SITE
Area of exposure: eye
% coverage: No data
Type of wrap if used: no wrap used
REMOVAL OF TEST SUBSTANCE
Washing (if done): no data
Time after start of exposure: no data
SCORING SYSTEM:
Grade 1 indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 ml, and Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Irritant / corrosive response data:
- Slight Irritation was observed
Any other information on results incl. tables
Table: Primary Irritation Index
Name of the test chemical |
Degree of eye injury in rabbits |
Vinyl propanoate |
2 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Primary Irritation score after 24 hours for vinyl propanoate was Grade 2.
In the acute eye irritation study conducted in albino rabbits, vinyl propanoate was considered to be slightly irritating to rabbit eyes. - Executive summary:
Acute eye irritation study was carried out to assess the toxicity of vinyl propanoate in rabbits.
Eye injury in rabbits is recorded in a 10- grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemical.Grade 1 indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 ml, and Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol.
Primary Irritation score after 24 hours for vinyl propanoate was Grade 2.
In the acute eye irritation study conducted in albino rabbits,vinyl propanoate was considered to be slightly irritating to rabbit eyes.
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