Phenethyl valerate

Endpoint summary

Description of key information

Short term to xicity to aquatic invertebrate

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity to Daphnia magna and cyanobacteria was predicted 2-phenylethyl pentanoate (CAS: 7460-74-4). Intoxication value was estimated to be 119.66 mg/l for Daphnia magna for 48 hrs duration. It was concluded that 2-phenylethyl pentanoate (CAS: 7460-74-4) was likely to be not toxic to aquatic invertebrate.

Toxicity aquatic algae and cyanobacteria

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on algae was predicted for 2-phenylethyl pentanoate (CAS: 7460-74-4). Effect concentration i.e EC50 value was estimated to be 105.68 mg/l for Pseudokirchneriella subcapitata for 72 hrs duration. It was concluded that the 2-phenylethyl pentanoate (CAS: 7460-74-4) was likely to be not-toxic to aquatic algae, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.

Additional information

Short term to xicity to aquatic invertebrate

Following studies include the predicted data and experimental study for the target chemical and structurally similar read across to conclude the toxicity extent of 2-phenylethyl pentanoate (CAS: 7460-74 4) towards aquatic inverterateis summarized as follows:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity to Daphnia magna and cyanobacteria was predicted 2-phenylethyl pentanoate (CAS: 7460-74-4). Intoxication value was estimated to be 119.66 mg/l for Daphnia magna for 48 hrs duration. It was concluded that 2-phenylethyl pentanoate (CAS: 7460-74-4) was likely to be not toxic to aquatic invertebrate.

The above predicted results for target assisted by experimental data of read across chemical (CAS: 19329 -89 -6) from the publication chemisphere 1998, suggests thatThe Effective concentration EC50 to 50% of Daphnia magna when exposed to Isopentyl lactate for 48 h is 193 mg/L. Decreasing trend of mobility effect of Daphnia magna was recorded during the test. It can be concluded from the value that the Isopentyl lactateis ont toxic to the aquatic invertebrate.

Further it is supported by the experimental study of structurally similar readIsopropyl lactate (CAS: 617-51-6)from the publication chemisphere 1998, suggests thatShort-term toxicity to aquatic invertebrates test was carried out under static condition for 48h to study the effects of Isopropyl lactate on aquatic environment. Decreasing trend of mobility effect of Daphnia magna was recorded during the test. The Effective concentration EC50 to 50% of Daphnia magna when exposed to Isopropyl lactate for 48 h is 802 mg/L. It can be concluded from the value that the Isopropyl lactate is not toxic to the aquatic invertebrate and can be considered as “not classified” as per the CLP classification criteria for aquatic environment.

Thus based on the effect concentrations which is in the range 119 mg/l to 802 mg/l give the conclusion that test substance 2-phenylethyl pentanoate (CAS: 7460-74-4) was likely to be not toxic to aquatic invertebrate at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be“not classified”as per the CLP classification criteria for aquatic environment.

Toxicity aquatic algae and cyanobacteria

Following studies include the predicted data and experimental study for the target chemical and structurally similar read across to conclude the toxicity extent of 2-phenylethyl pentanoate (CAS: 7460-74 4) towards aquatic algae is summarized as follows:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on algae was predicted for 2-phenylethyl pentanoate (CAS: 7460-74-4). Effect concentration i.e EC50 value was estimated to be 105.68 mg/l for Pseudokirchneriella subcapitata for 72 hrs duration. It was concluded that the 2-phenylethyl pentanoate (CAS: 7460-74-4) was likely to be not-toxic to aquatic algae, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.

The above predicted results for target assisted by experimental data of read across chemical (CAS: 19329 -89 -6) from the publication chemisphere 1998, suggests thatToxicity to aquatic algae and cyanobacteria test was carried out for 72-96 hr under static condition to study the effects of Isopentyl lactate on aquatic invertebrate. Decreasing trend of Population growth rate was recorded during the test.

Effective concentration EC50 to 50% of Pseudokirchneriella subcapitata at 72-96hr when exposed to Isopentyl lactate is 320 mg/L. Decreasing trend ofPopulation growth rate was recorded during the test. It can be concluded from the value that theIsopentyl lactate is not toxic to the aquatic algae and can be considered as “not classified” as per classification criteria for aquatic environment.

Further it is supported by the experimental study of structurally similar readIsopropyl lactate (CAS: 617-51-6)from the publication chemisphere 1998, suggests that theToxicity to aquatic algae and cyanobacteria test was carried out for 72-96 hr under static condition to study the effects of Isopropyl lactate on aquatic invertebrate. Decreasing trend ofbiomasswas recorded during the test.Effective concentration EC50 to 50% of Pseudokirchneriella subcapitata at 72-96hr when exposed to Isopentyl lactate is 180 mg/L.It can be concluded from the value that theIsopropyl lactate is not toxic to the aquatic algae and can be considered as “not classified” as per classification criteria for aquatic environment.

Thus based on the effect concentrations which is in the range 105.68 mg/l to 320 mg/l give the conclusion that test substance 2-phenylethyl pentanoate (CAS: 7460-74-4) was likely to be not toxic to aquatic algae at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be“not classified”as per the CLP classification criteria for aquatic environment.