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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: data is from publication
Justification for type of information:
Data is from peer reviewed journals

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance material review on phenethyl butyrate
Author:
D. McGinty, C.S. Letizia, A.M. Api
Year:
2012
Bibliographic source:
Food and Chemical Toxicology, 50 (2012) S398–S401
Reference Type:
publication
Title:
A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients.
Author:
The RIFM Expert Panel,D. Belsito , D. Bickers , M. Bruze , P. Calow , M.L. Dagli , A.D. Fryer ,H. Greim , Y. Miyachi , J.H. Saurat , I.G. Sipes
Year:
2012
Bibliographic source:
Food and Chemical Toxicology 50 (2012) S269–S313

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
Skin irritation test was conducted on 25 healthy patients to observe the irrritation potential of test chemical phenethyl butyrate (CAS No: 103-52-6).
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenethyl butyrate
EC Number:
203-119-8
EC Name:
Phenethyl butyrate
Cas Number:
103-52-6
Molecular formula:
C12H16O2
IUPAC Name:
2-phenylethyl butyrate
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Phenethyl butyrate
- Molecular formula: C12H16O2
- Molecular weight: 192.256g/mol
- Smiles: c1(CCOC(CCC)=O)ccccc1
- InChl): - 1S/C12H16O2/c1-2-6-12(13)14-10-9-11-7-4-3-5-8-11/h3-5,7-8H,2,6,9-10H2,1H3
-Substance type: organic
- Physical state: liquid
Specific details on test material used for the study:
Name of test material (as cited in study report): Phenethyl butyrate
- Molecular formula: C12H16O2
- Molecular weight: 192.256g/mol
- Smiles: c1(CCOC(CCC)=O)ccccc1
- InChl): - 1S/C12H16O2/c1-2-6-12(13)14-10-9-11-7-4-3-5-8-11/h3-5,7-8H,2,6,9-10H2,1H3
-Substance type: organic
- Physical state: liquid

Test animals

Species:
other: Human
Strain:
not specified
Details on test animals or test system and environmental conditions:
8% concentration of phenethyl butyrate in petrolatum was applied under occlusion for 48 h to the forearm or back of 25 healthy patients.

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: petrolatum
Controls:
not specified
Amount / concentration applied:
8%
Duration of treatment / exposure:
48 hours
Observation period:
no data
Number of animals:
25 healthy patients
Details on study design:
no data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
no data
Remarks on result:
other: Non-irritating
Irritant / corrosive response data:
No irritation was observed in 25 healthy patients.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test chemical phenethyl butyrate (CAS No: 103-52-6) was considered to be not irritating on skin of 25 healthy patients.
Executive summary:

A maximization test was conducted on25 healthy patients (male and female) for test chemical phenethyl butyrate (CAS No: 103-52-6) to assess its irritation potential.

 

During the test, 8% concentration of phenethyl butyrate in petrolatum was applied under occlusion for 48 h to the forearm or back of 25 healthy patients and then observations were made.

 

There was no irritation seen in any of the 25 patients. Hencethe test chemical phenethyl butyrate (CAS No: 103-52-6) was considered to be not irritating on skin of 25 healthy patients.