Phenethyl valerate

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal.

Data source

Reference

Reference Type:

publication

Title:

Acute Toxicity Studies with Insect Attractants

Author:

Morton Beroza, M. N. Inscoe, P. H. Schwartz, Jr., M. L. Keplinger, and C. W. Mastri

Year:

1975

Bibliographic source:

Toxicology and Applied Pharmacology 31,421-429

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To assess the ocular irritation potential of Phenethyl Propionate on New Zealand white rabbits according to Draize method.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Phenethyl propionate

EC Number:

204-567-7

EC Name:

Phenethyl propionate

Cas Number:

122-70-3

Molecular formula:

C11H14O2

IUPAC Name:

2-phenylethyl propanoate

Test material form:

liquid

Details on test material:

IUPAC:Phenethyl Propionate
Molecular formula :Molecular formula
Molecular weight :178.2296 g/mol
substance type:Organic
InChI:1S/C11H14O2/c1-2-11(12)13-9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3e
Smiles :c1(CCOC(=O)CC)ccccc1

Specific details on test material used for the study:

IUPAC:Phenethyl Propionate
Molecular formula :Molecular formula
Molecular weight :178.2296 g/mol
substance type:Organic
InChI:1S/C11H14O2/c1-2-11(12)13-9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3e
Smiles :c1(CCOC(=O)CC)ccccc1

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Details on test animals or tissues and environmental conditions:

Weight at study initiation: 1.9-3.1 kg
Sex:Male and Female
Total no of rabbits: 6

Test system

Vehicle:

unchanged (no vehicle)

Amount / concentration applied:

0.1 ml per dose

Duration of treatment / exposure:

24 hours

Observation period (in vivo):

1,24,48, 72 hours and 7 days

Details on study design:

SCORING SYSTEM: Draize method

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

7 d

Score:

0

Max. score:

110

Reversibility:

fully reversible within: 3 days

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No ocular reactions were observed.

Any other information on results incl. tables

Table 1: Primary Irritation score in rabbits

Time Point	Primary Irritation Score
1 hour	12
24 hour	7.5
48 hours	4.6
72 hours	0
7 days	0

Applicant's summary and conclusion

Interpretation of results:

other: Not eye irritant

Conclusions:

Phenethyl propionate was evaluated for primary eye irritation in rabbits ,slight irritation was observed on day 1 which got cleared till day 3.The primary irritation score after 7 days was 0. Hence Phenethyl propionate is considered not irritating to rabbit eye.

Executive summary:

Phenethyl propionate was evaluated for primary eye irritation in rabbits.

 The eye-irritating properties of the test material were determined by instilling a 0.1ml dose of undiluted sample into the conjunctival sac of the right eye of each of six rabbits; the left eye of each animal served as the control.

Grading for eye injury was made at 1 , 24, 48 and 72 hr and at 7 days after treatment according to the grading and scoring system of Draize et al. (1944) in which a zero score indicates no irritation and the maximum score at any one scoring period is 110 (maximum irritation and damage to the cornea, iris, and conjunctiva).

 Slight irritation was observed on day 1 which got cleared till day 3.The primary irritation score after 7 days was 0.

Hence,Phenethyl Propionate was considered not an eye irritant in rabbits.