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Diss Factsheets
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EC number: 214-540-1 | CAS number: 1143-72-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was conducted according to the Draize protocol (occlusive dressing, 24 h exposure period, abraded and intact test sites). Restrictions of the study: reading time point after 48 h missing, no individual scores, observation period terminated after 72 h
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,3,4-trihydroxybenzophenone
- EC Number:
- 214-540-1
- EC Name:
- 2,3,4-trihydroxybenzophenone
- Cas Number:
- 1143-72-2
- Molecular formula:
- C13H10O4
- IUPAC Name:
- 4-benzoylbenzene-1,2,3-triol
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elkhorn Rabbitry of Watsonville, CA, USA
- Weight at study initiation: 2 - 3 kg
- Housing: Animals were individually housed in hanging wire cages.
- Diet: Approximately 150 g of a commercial rabbit chow (Purina Rabbit Chow Complete Blend); fresh vegetables on occasion.
- Water: UV-purified drinking water, ad libitum.
- Acclimation period: 4 - 5 days
ENVIRONMENTAL CONDITIONS
- Air changes (per hr): air-conditioned rooms
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 g
- Duration of treatment / exposure:
- 24 h
- Observation period:
- Reading time points: 24 and 72 h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: Two unabraded and two abraded test sites were used on the dorsal area of the trunk of each rabbit. The back of each rabbit was clipped free of hair the day before treatment.
- Type of wrap if used: Each application site was covered with a gauze pad and the entire back was wrapped with a rubber dam.
OBSERVATION TIME POINTS: 24 and 72 h
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of all 6 animals
- Time point:
- 24 h
- Remarks on result:
- other: no individual Draize scores were given in the study report
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of all 6 animals
- Time point:
- 24 h
- Remarks on result:
- other: no individual Draize scores were given in the study report
- Irritation parameter:
- erythema score
- Time point:
- 48 h
- Remarks on result:
- other: animals were not observed at the 48-h reading time point
- Irritation parameter:
- edema score
- Time point:
- 48 h
- Remarks on result:
- other: animals were not observed at the 48-h reading time point
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- mean of all 6 animals
- Time point:
- 72 h
- Remarks on result:
- other: no individual Draize scores were given in the study report
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- mean of all animals
- Time point:
- 72 h
- Remarks on result:
- other: no individual Draize scores were given in the study report
- Irritant / corrosive response data:
- 24 h after the application of the test substance barely perceptible to slight erythema at the treated sites in 4/6 animals were observed. 72 h after treatment a few scattered sites continued to have barely perceptible erythema. No edema was observed in any animal after 24 h and 72 h of observation. The primary irritation score was calculated to be 0.6.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Remarks:
- As worst case assessment the test substance is considered as irritant to the skin.
- Conclusions:
- The test item is considered a very mild irritant to skin.
- Executive summary:
A study was conducted to evaluate the potential to cause skin irritation. Six male rabbits were treated with undiluted test item. The back of each rabbit was clipped free of hair the day before treatment. Two unabraded and two abraded test sites were used on the dorsal area of the trunk of each rabbit. Each application site was covered with a gauze pad and the entire back was wrapped with a rubber dam. After 24 h the pads and wraps were removed and sites were scored for erythema and edema after 24 and 72 h according to Draize test grading system. 24 h after the application of the test substance barely perceptible to slight erythema at the treated sites in 4/6 animals were observed. 72 h after treatment a few scattered sites continued to have barely perceptible erythema. No edema was observed in any animal after 24 h and 72 h of observation. The primary irritation score was calculated to be 0.6. The test item is considered a very mild irritant to skin.
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