Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin irritation – Irritating in rabbit (OECD TG 404). Mean erythema score (5 treated animals; 24, 48, 72 hr average): 2.56.
Eye irritation – Not irritating in rabbit (OECD TG 405). Mean conjunctival score (24, 48, 72 hour average): 0.05.

Key value for chemical safety assessment

Additional information

The human literature indicates that gasoline and naphtha blending stocks produce some dermal irritation but do not appear to be severe dermal irritants or corrosive agents. There is some evidence of eye irritation associated with vapor exposure at levels equal to and greater than 200 ppm, but the effects were mild, and the dose-response information was not conclusive. Similarly, gasoline and naphtha blending stocks produced some dermal irritation but not corrosion when applied to rabbit skin. The level of irritation was enhanced when the test materials were applied under occluded patch. There was very little evidence of irritation when these materials were instilled into rabbit eyes.

Justification for classification or non-classification

The animal studies were conducted under regulatory guidelines and in accordance with good laboratory practice recommendations. The data can be used without restriction for regulatory purposes. There is no need to conduct additional animal testing for these endpoints.