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EC number: 296-665-1 | CAS number: 92908-36-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Read-across with CAS 68411-81-4 (mean
measured):
EC10 (72 h; growth rate) = 63.5 mg/L
EC50 (72 h; growth rate) > 127.5 mg/L
NOEC (72 h; growth rate) = 16.8 mg/L
Read-across with CAS 92908-35-5 (nominal):
EC50 (72 h; growth rate) = 165 mg/L
NOEC (72 h, growth rate) = 30 mg/L
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 127.5 mg/L
- EC10 or NOEC for freshwater algae:
- 63.8 mg/L
Additional information
A toxicity study with the test substance in
aquatic algae is not available, but two tests with structural analogue
substances were performed. The results were evaluated in a weigt of
evidance approach.
A freswater algae test with Scenedesmus
subspicatus is available (RCC, 852787, 2004). The substance tested in
algae (CAS number 68411-81-4) is very similar to the submission
substance and is manufactured in the same way, namely the reaction of
glyoxal, urea and formaldehyde followed by methylation using methanol.
In the toxicity test on freshwater algae (Scenedesmus subspicatus)
according to OECD 201 and compliant to GLP, the following effect
concentrations (based on active ingredient, CAS 68411-81-4) had been
determined (mean measured concentrations):
NOEC (72h; biomass, growth rate) = 16.8 mg/L;
LOEC (72h; biomass, growth rate) = 40.8 mg/L;
EC10 (72h; biomass) = 41.5 mg/L;
EC10 (72 h; growth rate) = 63.5 mg/L;
EC50 (72h; biomass) = 111.7 g/L;
EC50 (72h; growth rate) > 127.5 mg/L;
Additionally, a valid algae test according to OECD guideline 201 with
the close structural analogue, Urea, reaction products with formaldehyde
and glyoxal (CAS 92908-35-5; BASF, 60E0760/083552, 2010). In the study
Pseudokirchnerella subcapitata was exposed to the analogue substance for
72 hours. Based on the algal growth rate an EC50 of 220 mg/L and a NOEC
of 40 mg/L were determined at test termination. The results refer to the
nominal test concentration based on substance mass without correction
for purity. Corrected for active ingredient, the results were EC50 (72h)
165 mg/L and NOEC (72h) 30 mg/L, respectively.
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