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Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27-August-1981 to 08-September-1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Study was not conducted under GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Principles of method if other than guideline:
Guideline for Acute Eye Irritation Testing, interagency regulatory liaison group CPSC, EPA, FDA, OSHA, Jan. 1981
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chlorododecane
EC Number:
203-981-5
EC Name:
1-chlorododecane
Cas Number:
112-52-7
Molecular formula:
C12H25Cl
IUPAC Name:
1-chlorododecane
Test material form:
liquid
Details on test material:
Test substance: as prescribed by 1.1 - 1.4

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS:
- Strain: Rabbit / New Zealand White
- Number and sex: 6 animals (3 males and 3 females)
- Acclimation period: 4 days

ENVIRONMENTAL CONDITIONS:
- Diet: standard Kliba 23/341/1
- Water: tab water ad libitum
- Housing in groups of 5 animals in MAKROLON cages (type III)
- Temperature: 20°C ± 2°C
- Rel. Humidity: 55% ± 10%
- Light/dark period: 12/12h

Test system

Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Amount / concentration applied:
undiluted
Amount applied: 0.1 mL
Duration of treatment / exposure:
Single instillation into the eye.
Observation period (in vivo):
observation period 3 weeks after instillation of the compound into the eye
Number of animals or in vitro replicates:
6
Details on study design:
In 3 of 6 animals the eyes were flushed with physiological saline 30 seconds after treatment.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
3
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
Laurylchlorid showed no irritation to rinsed and non-rinsed eyes when applied on the rabbit eye mucosa.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Laurylchlorid showed no irritation to rinsed and non-rinsed eyes when applied on the rabbit eye mucosa. Thus, according to Regulation (EC) 1272/2008 the data are conclusive but not sufficient for classification.