Nonanoic acid, mixed esters with heptanoic acid, pentaerythritol and valeric acid

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Refer to analogue justification document provided in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Duration:

21 d

Dose descriptor:

NOELR

Effect conc.:

>= 135 mg/L

Nominal / measured:

nominal

Conc. based on:

other:

Remarks:

test mat./WAF

Basis for effect:

reproduction

Remarks on result:

other:

Remarks:

source, RA-A, CAS 71010-76-9, Exxon, 2012, D. magna 21 d, RL1

Description of key information

No effects up to the limit of water solubility; read-across.

Additional information

No study investigating the long-term toxicity of Monopentaerythritol tetraesters and dipentaerythritol hexaesters of valeric, heptanoic and nonanoic acids to aquatic invertebrates is available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) is applied.

Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substance, the source substance is considered a suitable representative for the evaluation of the short-term toxicity of the target substance to aquatic invertebrates. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.

The study investigated the chronic toxicity of Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) to aquatic invertebrates according to OECD guideline 211.Daphnia magna was exposed to the test substance in a semi-static test system. The water accommodated fraction (WAF) was used for the preparation of the test solutions. A loading rate of 135 mg/L (nominal) was applied in the limit test. No significant effect on reproduction was observed in the treatment throughout the test period of 21 d. Hence, the 21 d-NOELR is determined to be ≥ 135 mg/L on the basis of the nominal test concentration.

Based on the available results from a structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Monopentaerythritol tetraesters and dipentaerythritol hexaesters of valeric, heptanoic and nonanoic acids will not exhibit long-term effects to aquatic invertebrates up to the limit of water solubility.