Registration Dossier
Registration Dossier
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EC number: 221-508-0 | CAS number: 3126-80-5
Endpoint summary
Administrative data
Description of key information
Additional information
Abiotic degradation
No information concerning photodegradation in water or soil is available for the tetrakis(2-ethylhexyl) benzene-1,2,4,5-tetracarboxylate. This information is not required according to REACH Regulation Annex VIII.
The stability of the substance against hydrolysis was calculated using HYDROWIN from EPI Suite v4.1 software.
A based catalyzed hydrolysis rate constant (Kb) for pH > 8 at 25 deg C equal at 1.316 L/mol-sec was estimated using a structure estimation method. This corresponds to half-lives of 6.1 days at pH 8 and 60.9 days at pH 7.
Biotic degradation
Key information:
Determination of 'Ready' Biodegradability was performed in a Carbon Dioxide (CO2) Evolution Test (Modified Sturm Test) in compliance with the OECD guideline No. 301 B (1992) (Timmer, 2018). In addition, the procedures were designed to meet the test methods of the ISO standard 10634, 1995. The study was conducted according to GLP. The test item was tested in duplicate at a target concentration of 16.5 mg/L, corresponding to 12 mg TOC/L. The organic carbon content was based on the molecular formula. The Theoretical CO2 production (ThCO2) of the test substance was calculated to be 2.63 mg CO2/mg. The relative biodegradation values calculated from the measurements performed during the test period revealed 13% and 0% biodegradation of test item (based on ThCO2), for the duplicate bottles tested. Thus, the criterion for ready biodegradability (at least 60% biodegradation within a 10 -day window) was not met. In conclusion, test substance was not readily biodegradable under the conditions of the modified Sturm test presently performed.
Supporting information:
Ready Biodegradability Sarpy rule set by Istituto di Ricerche Farmacologiche Mario Negri from VEGA QSAR Model for tetrakis(2-ethylhexyl) benzene-1,2,4,5-tetracarboxylate:
Prediction is NON Readily Biodegradable using the model.
The substance is not readily biodegradable.
BIOWIN 1 and 2 models by EPI Suite software v4.1.
Prediction is "biodegrades fast".
The substance is expected to biodegrade fast.
Biowin 3 from EPI Suite v4.1 software: the expected ultimate biodegradation timeframe is days to weeks
Biowin 4 from EPI Suite v4.1 software: the expected primary biodegradation timeframe is days
Biowin 5 from EPI Suite v4.1 software: the substance is expected to be readily biodegradable.
Biowin 6 from EPI Suite v4.1 software: the substance is expected to be readily biodegradable.
The substance is expected to biodegrade fast.
Bioaccumulation
The estimated bioconcentration factor Log BCF using BCFBAF model from EPI Suite Software v4.1 for tetrakis(2-ethylhexyl) benzene-1,2,4,5-tetracarboxylate is 0.5
The test substance has a low bioaccumulation potential.
The estimated bioconcentration factor Log BCF using Arnot-Gobas model from EPI Suite Software v4.1 is Log BCF (upper trophic) = -0.048 (BCF = 0.8944 L/kg wet-wt)
The estimated bioaccumulation factor Log BAF using Arnot-Gobas model from EPI Suite Software v4.1 is Log BAF (upper trophic) = 0.898 (BAF = 7.899 L/kg wet-wt)
The estimated BCF using CAESAR model, implemented in the QSAR platform VEGA, is 4 L/kg (Log BCF = 0.6)
Transport and distribution
In the key study (Volic, 2018) the log Koc has been determined according to OECD Guideline 121 to be greater then 5.63.
In the supporting QSAR calculations of tetrakis(2-ethylhexyl) benzene-1,2,4,5-tetracarboxylatethe following data has been evaluated for adsorption/desorption:
The estimated soil adsorption coefficient Log Koc using MCI model from EPI Suite Software v4.1 is 10.58
The estimated soil adsorption coefficient Log Koc using Log Kow model from EPI Suite Software v4.1 is 4.12
According to the McCall classification scheme of soil mobility potential, Log Koc above 8.97 means the substance is immobile in soil.
Henry's law constant at 25°C is 2.59E-008 atm-m3/mole(2.62E-003 Pa-m3/mole) calculated withEPI Suite v4.1 software. The substance is not in the applicability domain of MW range of 26.04 – 451.74, the substance has a MW of 703.02 g/mol
No GLP criteria are applicable for the usage of this tool, but due to the fact that it is a scientifically accepted calculation method the estimations performed are reliable with restrictions and can be used for the chemical safety assessment.
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