Alcohols, C8-18, ethoxylated

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two toxicity study to aquatic algae and cyanobacteria for the test chemical :
1 . and 2. To evalute the toxicity of test chemical on aquatic algae.

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: 1. Desmodesmus subspicatus, 2. Pseudokirchneriella subcapitata

Details on test organisms:

1. common name: Green Algae
age: Exponential growth phase (log)
COMMENT: 10000 CELLS/ML

Test type:

static

Water media type:

freshwater

Total exposure duration:

72 h

Test temperature:

1. 23 C

Nominal and measured concentrations:

2. 10 compositions

Details on test conditions:

1. 3 REPLICATES, MINERAL SALT TEST MEDIUM

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

6.61 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: Read across 1

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

1 100 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: Read across 2

Details on results:

2. - Exponential growth in the control (for algal test): yes, 16 fold increase seen over test period.

Conclusions:

The test chemical Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) is not likely to be toxic to aquatic algae at least in the dose range of 6.61-1100 mg/l.

Executive summary:

Following studies of structurally andfunctionallysimilar read across has ben assessed to conclude the toxicity extent of Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) towards aquatic algae is summarized as follows:

To study the effects of Dodecan-1-ol, ethoxylated toxicity to aquatic algae and cyanobacteria test was carried out for 72 hr.

Effective concentration EC50 to 50% of Desmodesmus subspicatus when expeosed to Dodecan-1-ol, ethoxylated for 72 hr is 6.61 mg/L.

The BCF value of Dodecan-1 -ol, ethoxylated reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

Toxicity to aquaic algae and cyanobacteria was carried for 72 hr with 2-(2-butoxyethoxy)ethanol to study the effects on aquatic algae.

The effective concentrations EC50 to 50% of Pseudokirchneriella subcapitata in 72 hr is 1100 mg/L. It can be concluded from the grwoth rate value that the 2-(2-butoxyethoxy)ethanol (CAS: 112-34-5) is not toxic to the aquatic algae and can be considered as “not classified” as per the classification criteria for aquatic environment.

Thus based on the effect concentrations of structurally and functionally similar read across it gives the conclusion that test substance Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) is likely to be not toxic to aquatic environment at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be “not classified” as per the CLP classification criteria.

Description of key information

Following studies of structurally andfunctionallysimilar read across has ben assessed to conclude the toxicity extent of Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) towards aquatic algae is summarized as follows:

To study the effects of Dodecan-1-ol, ethoxylated toxicity to aquatic algae and cyanobacteria test was carried out for 72 hr.

Effective concentration EC50 to 50% of Desmodesmus subspicatus when expeosed to Dodecan-1-ol, ethoxylated for 72 hr is 6.61 mg/L.

The BCF value of Dodecan-1 -ol, ethoxylated reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

Toxicity to aquaic algae and cyanobacteria was carried for 72 hr with 2-(2-butoxyethoxy)ethanol to study the effects on aquatic algae.

The effective concentrations EC50 to 50% of Pseudokirchneriella subcapitata in 72 hr is 1100 mg/L. It can be concluded from the grwoth rate value that the 2-(2-butoxyethoxy)ethanol (CAS: 112-34-5) is not toxic to the aquatic algae and can be considered as “not classified” as per the classification criteria for aquatic environment.

Thus based on the effect concentrations of structurally andfunctionallysimilar read across it gives the conclusion that test substance Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) is likely to be not toxic to aquatic environment at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be “not classified” as per the CLP classification criteria.

Key value for chemical safety assessment

EC50 for freshwater algae:

1 100 mg/L

Additional information

Following studies of structurally andfunctionallysimilar read across has ben assessed to conclude the toxicity extent of Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) towards aquatic algae is summarized as follows:

To study the effects of Dodecan-1-ol, ethoxylated toxicity to aquatic algae and cyanobacteria test was carried out for 72 hr.

Effective concentration EC50 to 50% of Desmodesmus subspicatus when expeosed to Dodecan-1-ol, ethoxylated for 72 hr is 6.61 mg/L.

The BCF value of Dodecan-1 -ol, ethoxylated reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

Toxicity to aquaic algae and cyanobacteria was carried for 72 hr with 2-(2-butoxyethoxy)ethanol to study the effects on aquatic algae.

The effective concentrations EC50 to 50% of Pseudokirchneriella subcapitata in 72 hr is 1100 mg/L. It can be concluded from the grwoth rate value that the 2-(2-butoxyethoxy)ethanol (CAS: 112-34-5) is not toxic to the aquatic algae and can be considered as “not classified” as per the classification criteria for aquatic environment.

Thus based on the effect concentrations of structurally andfunctionallysimilar read across it gives the conclusion that test substance Alcohols, C8-18, ethoxylated (CAS: 157707-43-2) is likely to be not toxic to aquatic environment at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be “not classified” as per the CLP classification criteria.