Ammonium iodide

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

for read across substance

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two short term toxicity study of microorganism for the test chemical :
1.To evaluate toxicity of test chemical on Staphylococcus auerus (JKB068)
2.To evaluate antibacterial activity of test chemical

Specific details on test material used for the study:

- Name of test material: Ammonium iodide
- IUPAC name: Ammonium iodide
- Molecular formula: H4IN
- Molecular weight: 144.939 g/mole
- Smiles : [NH4+].[IH-]
- Inchl: 1S/HI.H3N/h1H;1H3
- Substance type: Inorganic
- Physical state: Solid crystalline powder (colorless to white)

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: Staphylococcus auerus (JKB068) , Bacillus subtilis

Details on inoculum:

1.Nutrient agar plates containing various concentrations of potassium iodide were prepared in quintuplicate. The above mentioned organisms were inoculated by standardized loops.

Test type:

static

Water media type:

other: Nutrient medium

Limit test:

no

Total exposure duration:

24 h

Test temperature:

1.37 deg C

Reference substance (positive control):

not specified

Duration:

24 h

Dose descriptor:

other: minimum inhibitory concentration

Effect conc.:

358.3 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other: Read across 1

Duration:

24 h

Dose descriptor:

IC50

Effect conc.:

500 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other: Read across 2

Validity criteria fulfilled:

not specified

Conclusions:

The test chemical Ammonium iodide is not likely to be toxic to microorganisms atleast in the dose range of 358-500 mg/l

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of micro-organisms for the test chemical Ammonium iodide (12027 -06 -4).The studies are as mentioned below:

1.Minimum Inhibitory Concentration (MIC100) value of test chemical in microorganism (Staphylococcus auerus) in a 24hrs. study on growth effect was found to be 358.3 ± 17.1 mg/L.It is concluded that test chemical does not exhibit toxicity to microorganism (Staphylococcus auerus)

2.The test chemical was used to evaluate minimum inhibition concentration on the test organism Bacillus subtilis after inoculation of test substance for 24 hrs the effect concentration was observed to be 500 mg/l

Description of key information

Toxicity to microorganism:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of micro-organisms for the test chemical Ammonium iodide (12027 -06 -4).The studies are as mentioned below:

1.Minimum Inhibitory Concentration (MIC100) value of test chemical in microorganism (Staphylococcus auerus) in a 24hrs. study on growth effect was found to be 358.3 ± 17.1 mg/L.It is concluded that test chemical does not exhibit toxicity to microorganism (Staphylococcus auerus)

2.The test chemical was used to evaluate minimum inhibition concentration on the test organism Bacillus subtilis after inoculation of test substance for 24 hrs the effect concentration was observed to be 500 mg/l

Key value for chemical safety assessment

EC50 for microorganisms:

500 mg/L

Additional information

Toxicity to microorganism:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of micro-organisms for the test chemical Ammonium iodide (12027 -06 -4).The studies are as mentioned below:

1.Minimum Inhibitory Concentration (MIC100) value of test chemical in microorganism (Staphylococcus auerus) in a 24hrs. study on growth effect was found to be 358.3 ± 17.1 mg/L.It is concluded that test chemical does not exhibit toxicity to microorganism (Staphylococcus auerus)

2.The test chemical was used to evaluate minimum inhibition concentration on the test organism Bacillus subtilis after inoculation of test substance for 24 hrs the effect concentration was observed to be 500 mg/l