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Diss Factsheets
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EC number: 946-937-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 August 2017 to 14 August 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- < -80 °C
- Conclusions:
- Under the conditions of this study it was concluded that the melting temperature of the test material is < -80°C (< 193K).
- Executive summary:
The melting point of the test material was investigated in accordance with the standardised guidelines OECD 102, EU Method A.1. and OPPTS 830.7200 under GLP conditions using the Differential Scanning Calorimetry. Under the conditions of this study it was concluded that the melting temperature of the test material is < -80°C (< 193K).
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 11 July 2009 to 15 August 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: "Guidelines for testing of chemicals", State Environmental Protection Administration (SEPA) of China, No.102
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- - Storage: cool and dark
- Key result
- Melting / freezing pt.:
- -4.1 °C
- Conclusions:
- Under the conditions of this study the melting point of the test material was -4.1°C.
- Executive summary:
The melting point of the test material was investigated in accordance with the standardised guideline: Guidelines for testing ofchemicals", State Environmental Protection Administration (SEPA) of China, No.102 with reference to OECD 102 and under GLP conditions. Results showed that there were 4 endothermic peaks as -49.6, -22.4, - 4.1 and -19.2°C. In view of the phenomenon that there is some semi-solid appearing with the conglutination increasing when stored below 0°C, it can be concluded that the melting point (freezing point) is around 0°C. Under the conditions of this study the melting point of the test material was -4.1°C.
Referenceopen allclose all
-Preliminary Test:
Starting at 225°C, the weight of the sample decreased significantly. At 298°C, the sample weight had decreased by 25%. After the experiment no residue was observed in the sample container.
- Main Study:
Experiment 1 - During cooling, no effects were observed which were due to crystallisation of the test material. During heating, an exothermic signal was observed between 300 and 350°C. After the experiment, however, it was observed that the sample container had fallen off its platform. This event might have caused the exothermic signal and it was decided not to consider it during data interpretation. A yellow/brown residue remained in the sample container. The change of the colour indicated reaction and/or decomposition of the test material.
Experiment 2 - Less test material was used. An endothermic peak was observed between 275 and 375°C. The endothermic effect was due to reaction and/or decomposition of the test material. After the experiment, a yellow/brown residue remained in the sample container (original colour: colourless). The change of the colour confirmed reaction and/or decomposition of the test material.
- An additional investigation of the melting temperature of the test material was performed placing two subsamples of the test material for 25 hours at -23.2 ± 0.4°C and at -82.0 ± 2.5°C, respectively. It was observed after storage that the test material was a very viscous liquid (in ¿ -15°C freezer and ¿ -75°C freezer). It was concluded that the melting temperature of the test material is < -80°C (< 193K).
Results showed that there are 4 endothermic peaks as -49.6, -22.4, - 4.1 and -19.2°C. As there is enantiomer and a little of impurity in this sample, more than one of the peaks appear in the curve. In view of the phenomenon that there is some semi-solid appearing with the conglutination increasing when stored below 0°C, it can be concluded that the melting point (freezing point) is around 0°C. - 4.1°C is considered to be the starting melting point (freezing point).
Description of key information
Under the conditions of this study it was concluded that the melting temperature of the test material is < -80°C (< 193K).
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- -80 °C
Additional information
Key Study (Reingruber, 2017)
The melting point of the test material was investigated in accordance with the standardised guidelines OECD 102, EU Method A.1. and OPPTS 830.7200 under GLP conditions using the Differential Scanning Calorimetry. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997). Under the conditions of the study, it was concluded that the melting temperature of the test material is < -80ºC (< 193K).
Supporting Study (He, 2009)
The melting point of the test material was investigated in accordance with the standardised guideline: Guidelines for testing of chemicals", State Environmental Protection Administration (SEPA) of China, No. 102 with reference to OECD 102 and under GLP conditions. The study was awarded a reliability score of 2 in accordance with the criteria set forth by Klimisch et al. (1997). Results showed that there are 4 endothermic peaks as -49.6, -22.4, - 4.1 and -19.2°C. As there is enantiomer and a little of impurity in this sample, more than one of the peaks appear in the curve. In view of the phenomenon that there is some semi-solid appearing with the conglutination increasing when stored below 0°C, it can be concluded that the melting point (freezing point) is around 0°C. - 4.1°C is considered to be the starting melting point (freezing point).
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