6-deoxy-L-mannose

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)

Deviations:

no

GLP compliance:

yes

Type of method:

sieving

Type of distribution:

other: dry sieve analysis for granular material

No.:

#1

Size:

>= 250 µm

Distribution:

78.8 %

No.:

#2

Size:

< 250 µm

Distribution:

21 %

No.:

#3

Size:

< 20 µm

Distribution:

ca. 0.2 %

Remarks on result:

other: distribution was negligible at <20 µm

No sieve clogging or static issues were observed at any point during the testing. For each subsample, over 99% of the test substance had particles either at or greater than ninety microns. The particle size distribution dramatically dropped off below ninety microns.

 

Particle Size Distribution Recovery Data for Sample ID: 112C-314-1
Sieve Size, µm	Beaker Weight (empty), g	Beaker Weight (w/residue), g	Residue Weight (g)	Percent^1Recovered
1000	111.1043	111.1153	0.0110	0.5
500	108.9491	109.6664	0.7173	35.2
250	111.1757	112.0504	0.8747	42.9
125	114.1203	114.5263	0.4060	19.9
90.0	104.8651	104.8864	0.0213	1.0
63.0	110.0129	110.0136	0.0007	< 0.1
45.0	110.7088	110.7088	0.0000	< 0.1
20.0	110.2907	110.2907	0.0000	< 0.1
< 20.0	113.6334	113.6334	0.0000	< 0.1
Initial sample weight (g) = 2.0378 Total weight recovered from sieves (g) = 2.0310 Total percent recovered = 99.7 % ^1Generated using Microsoft® Excel in full precision mode. Manual calculations may vary slightly.

 

Particle Size Distribution Recovery Data for Sample ID: 112C-314-2
Sieve Size, µm	Beaker Weight (empty), g	Beaker Weight (w/residue), g	Residue Weight (g)	Percent^1Recovered
1000	109.7367	109.7580	0.0213	1.0
500	111.7791	112.5169	0.7378	36.0
250	114.7180	115.5754	0.8574	41.9
125	112.1867	112.5990	0.4123	20.1
90.0	109.5676	109.5822	0.0146	0.7
63.0	109.7650	109.7663	0.0013	0.1
45.0	110.7088	110.7088	0.0000	< 0.1
20.0	110.2908	110.2908	0.0000	< 0.1
< 20.0	113.6335	113.6335	0.0000	< 0.1
Initial sample weight (g) = 2.0484 Total weight recovered from sieves (g) = 2.0447 Total percent recovered = 99.8 % ^1Generated using Microsoft® Excel in full precision mode. Manual calculations may vary slightly.

 

Particle Size Distribution Recovery Data: Range Determination
Sieve Size, µm	% Recovery Data 112-314-1	% Recovery Data 112-314-2	Range (%)
1000	0.5	1.0	0.5
500	35.2	36.0	0.8
250	42.9	41.9	1.0
125	19.9	20.1	0.2
90.0	1.0	0.7	0.3
63.0	< 0.1	0.1	0.1
45.0	< 0.1	< 0.1	< 0.1
20.0	< 0.1	< 0.1	< 0.1
< 20.0	< 0.1	< 0.1	< 0.1
Range = Abs ((% recovery data 122C-314-1) – (% recovery data 122C-314-2)); calculated for each sieve size. ^1Generated using Microsoft® Excel in full precision mode. Manual calculations may vary slightly.

 

Summary of Particle Size Distribution: Mean Percent Recovery
Sieve Size, µm	Mean Percent^1Recovered
1000	0.8
500	35.6
250	42.4
125	20.0
90.0	0.9
63.0	0.1
45.0	0.0
20.0	0.0
< 20.0	0.0
^1Generated using Microsoft® Excel in full precision mode. Manual calculations may vary slightly.

 

Conclusions:

78.8% of particulate matter was ≥250 µm
21.0% of particulate matter was <250 µm
Negligible (ca. 0.2%) amount of particulate matter was <20.0 µm

Executive summary:

The particle size distribution of the test substance was determined using dry sieve analysis for granular material in accordance with OECD guideline 110. The testing was performed in duplicate using two separate sub-samples. The test material subsample masses used were 2.0378 and 2.0484 grams. No sieve clogging or static issues were observed at any point during the testing. For each subsample, over 99% of the test substance had particles either at or greater than ninety microns. The particle size distribution dramatically dropped off below ninety microns. The average amount of particulate matter either at or larger than 250 microns in the test substance was 78.8%. The average amount of particulate matter smaller than 250 microns in the test substance was 21.0%. The average amount of particulate matter smaller than 20.0 microns in the test substance was negligible. The mean weight percent recovery for the two analyses was 99.8%.

Description of key information

OECD Guideline 110

Additional information

78.8% of particulate matter was ≥250 µm

21.0% of particulate matter was <250 µm

Negligible (ca. 0.2%) amount of particulate matter was <20.0 µm