Registration Dossier
Registration Dossier
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EC number: 222-793-4 | CAS number: 3615-41-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
- Remarks:
- for skin irritation see Section 7.10.3 DO.K2.SkIrrit.H.Pub
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics
- Author:
- Cosmetic Ingredient Review Expert Panel
- Year:
- 2 014
- Bibliographic source:
- Cosmetic Ingredient Review 2014, Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics, 2014: 31, Washington, DC, USA
- Report date:
- 2014
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Human repeated insult patch test was performed.
- GLP compliance:
- no
Test material
- Reference substance name:
- 6-deoxy-L-mannose
- EC Number:
- 222-793-4
- EC Name:
- 6-deoxy-L-mannose
- Cas Number:
- 3615-41-6
- Molecular formula:
- C6H12O5
- IUPAC Name:
- 6-deoxy-L-mannose
- Details on test material:
- -Purity: Not reported
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 106
- Sex: not reported
- Age: not reported - Clinical history:
- not reported
- Controls:
- not reported
- Route of administration:
- dermal
- Details on study design:
- The test substance was tested in an epicutaneous test with 48-72 hour occlusive patches of a leave on facial product containing 10% test substance, applied neat. Distilled water was used as a negative control.
Results and discussion
- Results of examinations:
- No sensitisation was observed in any test subject.
Applicant's summary and conclusion
- Conclusions:
- No sensitisation was observed in any test subject.
- Executive summary:
A leave-on facial product containing 10% of the test substance was examined in a Human Repeated Insult Patch Test (HPIPT) with 48-72 h occlusive patches. Distilled water was used as a negative control. The test substance as examined, was not a sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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