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EC number: 202-223-0 | CAS number: 93-15-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Year: 2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 72 h
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 22 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 4.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 9.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: area under growth curve
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: area under growth curve
- Validity criteria fulfilled:
- yes
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
not specififed
2. MODEL (incl. version number)
ECOSAR
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CAS 93-15-2
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
[Explain how the model fulfils the OECD principles for (Q)SAR model validation. Consider attaching the QMRF or providing a link]
- Defined endpoint: Acute 96-h algae growth inhibition
- Unambiguous algorithm: not specified
- Defined domain of applicability: not specified
- Appropriate measures of goodness-of-fit and robustness and predictivity: not specified
- Mechanistic interpretation: not specified
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- - Software tool(s) used including version:
not specified
- Model(s) used: ECOSAR
- Model description: see field 'Justification for non-standard information', 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information', 'Attached justification' - Analytical monitoring:
- not required
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 8.3 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Validity criteria fulfilled:
- yes
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- 1. SOFTWARE
Danish QSAR database
2. MODEL (incl. version number)
2017
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
c1(OC)c(OC)cc(CC=C)cc1
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
[Explain how the model fulfils the OECD principles for (Q)SAR model validation. Consider attaching the QMRF or providing a link]
- Defined endpoint: not specified
- Unambiguous algorithm: not specified
- Defined domain of applicability: not specified
- Appropriate measures of goodness-of-fit and robustness and predictivity: not specified
- Mechanistic interpretation: not specified
5. APPLICABILITY DOMAIN
[Explain how the substance falls within the applicability domain of the model]
- Descriptor domain: not specified
- Structural and mechanistic domains: not specifed
- Similarity with analogues in the training set: not specifed
- Other considerations (as appropriate): not specified
6. ADEQUACY OF THE RESULT
[Explain how the prediction fits the purpose of classification and labelling and/or risk assessment]
The results from the Danish QSAR database supports the risk characterization and classification and labelling that was demonstrated by the experimental results. - Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Software tool(s) used including version: Danish QSAR database
- Model(s) used: 2017
- Model description: see field 'Justification for non-standard information', 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information', 'Attached justification' - Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 11.972 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Validity criteria fulfilled:
- yes
Referenceopen allclose all
Description of key information
A study with the registered substance following the OECD guidance 201 and GLP was performed by the Ministry of Environment in Japan. The EC50 after 72h of exposure was found to be 22 mg/L while the NOEC was 4.6 mg/L. Furthermore a QSAR analysis by the Canadian authorities shows similar results with the 96h EC50, using ECOSAR models, is found to be 8.30 mg/L. Ultimately the Danish QSAR database showed similar results with values of 11.972 mg/L for the 96h EC50.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 22 mg/L
- EC10 or NOEC for freshwater algae:
- 4.6 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
