Registration Dossier
Registration Dossier
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EC number: 200-460-4 | CAS number: 60-18-4
Density
Administrative data
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15. - 17.11.2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- appearance / physical state / colour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24.10.2016 (issue date of the certificate of analysis)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test item related data in the study report are obtained from a certificate delivered by the sponsor. Methods are not specified.
- GLP compliance:
- not specified
- Other quality assurance:
- other: not specified
- Specific details on test material used for the study:
- purity: 99.9 w/w, Lot# 0011675004
- Physical state at 20°C and 1013 hPa:
- solid
- Key result
- Form:
- solid
- Colour:
- white
- Odour:
- other: not specified
- Substance type:
- organic
- Conclusions:
- The sample is solid and white of color at room temperature (20˚C).
- Executive summary:
The stated appearance of the test item L-Tyrosine (Lot# 0011675004, 99.9% pure) is based on the information of a certificate of analysis delivered by the sponsor. The used methods are nor specified.
The sample is a white solid at room temperature (20˚C)..
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- GLP compliance:
- yes (incl. QA statement)
- Other quality assurance:
- other: not applicable
- Type of method:
- air comparison pycnometer (for solids)
Test material
- Reference substance name:
- Tyrosine
- EC Number:
- 200-460-4
- EC Name:
- Tyrosine
- Cas Number:
- 60-18-4
- Molecular formula:
- C9H11NO3
- IUPAC Name:
- tyrosine
Constituent 1
- Specific details on test material used for the study:
- purity: 99.9% w/w
- Dynamic viscosity of test material:
- not specified
Results and discussion
Density
- Key result
- Type:
- relative density
- Density:
- 1.41
- Temp.:
- 20 °C
Any other information on results incl. tables
Density of L-Tyrosine
| Sample No. | Determined sample volume (cm3) | Weight test item (g) | Temperature (°C) | Density (g/cm*) | Realtive Density () |
| 1 | 3.12931 | 4.4102 | 20.00 | 1.4093 | 1.4093 |
| 2 | 2.73689 | 3.8611 | 20.00 | 1.4108 | 1.4108 |
| mean: | 20.00 | 1.4101 | 1.4101 | ||
| absolute deviation: | 0.00 | 0.0015 | 0.0015 | ||
| relative deviation: | 0.00 | 0.11 | 0.11 |
Applicant's summary and conclusion
- Conclusions:
- The mean relative density (D20/4) of L-Tyrosine was determined to be 1.4101 relating to the nominal density of water at 4°C (0.999972 g/cm3).
- Executive summary:
The relative density (D20/4) of L-Tyrosine was determined according to EC method A.3 and OECD TG 109 and under GLP compliance. The density of the test item was determined two times with individualy prepared samples. The relative deviation between two measurements was </= 0.5% and the quality criteria of the measurement were therefore fulfilled.
The mean relative density (D20/4) of L-Tyrosine was determined to be 1.4101 relating to the nominal density of water at 4°C (0.999972 g/cm3).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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