Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-875-0 | CAS number: 75-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Guidance on Safe Use
Administrative data
First-aid measures
General Advice: Remove to fresh air immediately. Get medical attention immediately. Show this material safety data sheet to the doctor in attendance. Take off contaminated clothing and shoes immediately. If symptoms persist, call a physician. Personal protective equipment for first aid responders is recommended.Eye Contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Remove contact lenses Obtain medical attention. Continue rinsing eyes during transport to hospitalSkin Contact: Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Consult a physician. Wash contaminated clothing before re-use. Thoroughly clean shoes before reuseInhalation: P340 - Remove to fresh air and keep at rest in a position comfortable for breathing. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Symptoms may be delayed. Immediate medical attention is requiredIngestion: Not applicableMost important symptoms and effects, both acute and delayed: • Causes severe caustic burns to skin and eyes• Contact can cause cold burns, frostbite and/or chemical burns with severe skin damage• Corrosive to the eyes and may cause severe damage including blindness• Harmful by inhalation• Irritating to respiratory system and skin• Inhalation of aerosol or skin contact may cause sensitization of susceptible persons• Bad and blurred vision• Reduced vision• Definitive loss of eye sight• Lachrymation• superficial burning sensation• Exposure may result in reddening, tears and itching of the eyes and soreness in the nose and throat, together withcoughing• Inhalation of vapors is irritating to the respiratory system, may cause throat pain and cough• Runny nose• Shortness of breath• Suffocation• Lung edema• Delayed effects can be expected and will be enforced by physical efforts• Is excreted into the sweat which can lead to an unpleasant body odour• Can influence the heart and vascular system with blushing and heart palpitations as a result• Can act on the upper and lower airways with inflamations and reduced lung function as a result• Can result in erosion of the teeth• Can result in function disruption of tke nervous system and the liverIndication of immediate medical attention and special treatment needed:• Consult a physician
Fire-fighting measures
Suitable Extinguishing Media: • carbon dioxide (CO2)• water spray• dry chemical• Alcohol-resistant foamExtinguishing media which must not be used for safety reasons: high volume water jetSpecific Hazards Arising from the Chemical:Specific hazards • Extremely flammable liquefied gas• Vapors are heavier than air and may spread along floors• Vapors may form explosive mixture with air• Heating or fire can release toxic gas (Nitrogen oxides (NOx), Carbon monoxide, Nitrosamine, Ammonia)Specific methods • DO NOT extinguish a gas fire unless effective immediate shut-off of gas flow is possible• In the event of fire, cool tanks with water spray• Keep product and empty container away from heat and sources of ignition• Collect contaminated fire extinguishing water separately. This must not be discharged into drains.Protective Equipment and Precautions for Firefighters:Wear full protective clothing and self-contained breathing apparatus
Accidental release measures
Personal precautions, protective equipment and emergency procedures:• Avoid contact with skin, eyes and clothing• Evacuate personnel to safe areas• Keep people away from and upwind of spill/leak• Wear self-contained breathing apparatus and protective suit• Rubber glovesEnvironmental precautions:• Remove immediately adhering matter• Hose down gases, fumes and/or dust with water• Prevent product from entering drains• Do not flush into surface water or sanitary sewer systemMethods and materials for containment and cleaning up:• Use explosion-proof equipment• Wear self-contained breathing apparatus and protective suit• Absorb spill with inert material (e.g. dry sand or earth), then place in a chemical waste container• Neutralize with hydrochloric or sulfuric acids
Handling and storage
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site.Precautions for safe handling:• Take necessary action to avoid static electricity discharge (which might cause ignition of organic vapours)• Use only in area provided with appropriate exhaust ventilation• Use spark-proof tools and explosion-proof equipment• Wear personal protective equipment• Do not eat, drink or smoke when using this product• Wash hands after handling• Remove contaminated clothing and protective equipment before entering eating areas• Ensure that eyewash stations and safety showers are close to the workstation location• Avoid breathing vapors or mistsConditions for safe storage, including any incompatibilities:• In accordance with local and national regulations• Keep container tightly closed• Keep in a dry, cool place• Keep away from open flames, hot surfaces and sources of ignition
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site.Control parameters - Exposure Guidelines:Chemical Name: TrimethylamineACGIH TLV: TWA: 5 ppm; STEL: 15 ppmExposure controls:Engineering Controls • Local exhaustPersonal Protective Equipment:Eye/face Protection • Respirator with a full face maskSkin Protection • Wear suitable protective equipment• Complete suit protecting against chemicalsHand Protection • Nitrile rubber• Neoprene gloves• Solvent-resistant gloves (butyl-rubber)• Protective gloves against cold• The selected protective gloves have to satisfy the specifications of EU Directive 89/689/EEC and the standard EN 374 derived from it• The suitability for a specific workplace should be discussed with the producers of the protective glovesRespiratory Protection • In the case of vapor formation use a respirator with filter model K• self-contained breathing apparatus (EN 133) (in case of higher concentration)Environmental exposure controls • Prevent product from entering drains• Do not contaminate surface water• Avoid subsoil penetration
Stability and reactivity
Reactivity:Chemical Stability:• Stable under normal conditions• Hazardous polymerisation does not occurPossibility of hazardous reactions: None under normal processingConditions to Avoid:• Heat, flames and sparks• Take necessary action to avoid static electricity discharge (which might cause ignition of organic vapors)• S 6 - Keep under nitrogenIncompatible materials to avoid: • Zinc• Copper• Aluminum• Strong acids and oxidizing agents• Halogenated hydrocarbonsHazardous Decomposition Products: • Heating or fire can release toxic gas (nitrogen oxides (NOx), Carbon monoxide, nitrosamine, Ammonia)
Disposal considerations
Waste Disposal Method• Should not be released into the environment• Dispose of contents/container in accordance with local regulationContaminated Packaging• Empty containers should be taken for local recycling, recovery or waste disposal
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.