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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
other: bibliography
Adequacy of study:
weight of evidence
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
according to guideline
Guideline:
other: Moreno protocol on essential oils
GLP compliance:
not specified
Species:
rat
Dose descriptor:
LD50
Effect level:
3 650 mg/kg bw
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 Rat oral of g-terpinene is 3650mg/kg.The substance is classified as a category 5 GHS regulation.
Endpoint:
acute toxicity: oral
Type of information:
other: bibliography
Adequacy of study:
weight of evidence
Study period:
2008
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data considered reliable by ECHA.
Qualifier:
no guideline available
Principles of method if other than guideline:
Unknown
GLP compliance:
not specified
Details on oral exposure:
LD50 Rat oral 2790 mg/kg (2440-3180, 95% CL) /From table/[Organization for Economic Cooperation and Development; Screening Information Data Set for LINALOOL (78-70-6) p.13 (March 2002). Available from, as of July 15, 2008: http://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html] **PEER REVIEWED**
Dose descriptor:
LD50
Effect level:
2 790 mg/kg bw
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 Rat oral 2790 mg/kg. The substance is classified as a category 5 GHS regulation.
Endpoint:
acute toxicity: oral
Type of information:
other: bibliography
Adequacy of study:
weight of evidence
Study period:
2006
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data considered reliable by ECHA.
Qualifier:
no guideline available
Principles of method if other than guideline:
Unknown
GLP compliance:
not specified
Details on test animals or test system and environmental conditions:
LD50 Rat oral 4750 mg/kg [O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ:Merck and Co., Inc., 2006., p. 464] **PEER REVIEWED**
Dose descriptor:
LD50
Effect level:
ca. 4 750 mg/kg bw
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 rat oral 4750 mg/kg body weight. The substance is classified as a category 5 GHS regulation.
Endpoint:
acute toxicity: oral
Type of information:
other: bibliography
Adequacy of study:
weight of evidence
Study period:
2000
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data considered reliable by ECHA.
Qualifier:
no guideline available
Principles of method if other than guideline:
Unknown
GLP compliance:
not specified
Details on oral exposure:
LD50 Rat oral 980 mg/kg [Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3463] **PEER REVIEWED**
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 980 mg/kg bw
Based on:
not specified
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 rat oral 980 mg/kg body weight

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Monograph used by the fragrance industry.
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
RIFM protocol in 1973
GLP compliance:
no
Species:
rat
Key result
Sex:
not specified
Dose descriptor:
approximate LD50
Effect level:
> 3 750 - < 5 670 mg/kg bw
Based on:
not specified
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The acute oral LD50 value in rats was reported 4.70 g/kg (Moreno, 1973).
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
discriminating dose
Value:
980 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification