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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propionic acid
EC Number:
201-176-3
EC Name:
Propionic acid
Cas Number:
79-09-4
Molecular formula:
C3H6O2
IUPAC Name:
propionic acid
Details on test material:
- Name of test material (as cited in study report): Propionsäure Hoe 31891
- Physical state: liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Hoechst AG, Pharma Forschung Toxicologie
- Weight at study initiation: 153 - 200g
- Housing: single housing
- Diet (e.g. ad libitum): ad libitum, ALTROMIN 1324 Atltogge Lage/Lippe
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: 30 cm²
- Type of wrap if used: covered with aluminium foil and elastic patch

REMOVAL OF TEST SUBSTANCE
- Washing (if done): after 24 hours, rinsed with warm water
Duration of exposure:
24 h
Doses:
1000, 2500, 3150, 4000 and 5000 mg/kg
No. of animals per sex per dose:
6
Details on study design:
- Duration of observation period following administration: 14 - 21 days
- Other examinations performed: clinical signs, pathology
Statistics:
Linder & Weber; Cavalli-Sforza

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
3 235 mg/kg bw
Mortality:
1000 mg/kg: 0/6
2500 mg/kg: 1/6
3150 mg/kg: 1/6
4000 mg/kg: 6/6
5000 mg/kg: 6/6
Clinical signs:
other: Animals found dead died in a narcotic like condition in abdominal position. The skin on the back was dicoloured brown,hard and necrotic.
Gross pathology:
sacrificed animals: no abnormality
animals found dead: 5000 mg/kg: 3 dead animals showed pale spotted liver and a bloody small intestine. Regarding to autolytic changes, no macroscopic assessement of the other dead animals was possible.

Applicant's summary and conclusion