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EC number: 451-200-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects to freshwater fish up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
In accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to four structurally related category members pentaerythritol tetraesters of n-decanoic, n-heptanoic, n-octanoic and n-valeric acids (CAS 68424-31-7), decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9), fatty acids, C5-9 tetraesters with pentaerythritol (CAS 67762-53-2) and fatty acids, C8-10 mixed esters with dipentaerythritol, isooctanoic acid, pentaerythritol and tripentaerythritol (CAS 189200-42-8) in order to fulfil the data requirements according to Annex VII-IX.
This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the category justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substances were used for the assessment. The first three read-across substances have the same alcohol component, i.e. pentaerythritol (the fourth additionally exhibits dipentaerythritol), and are tetra-esters with a fatty acid chain length within the range of C5 – C10 comparable to the target substance with chain length of C5. In the first key study, the short term toxicity of CAS 68424-31-7 to freshwater fish was investigated in a semi-static limit test (Combert and Caunter, 1991) conducted according to a guideline similar to OECD 203 using Salmo gairdneri as a test organism. This study determined LC50 (96h) > 1000 mg/L (nominal). The test material did not dissolved completely in the dilution water. No mortality was observed within the tested concentration (1000 mg/l nominal) during 96 h exposure under test conditions. Based on these results it can be concluded that no toxicological effects on freshwater fish are expected up to limit of water solubility. In a further study with decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS No. 71010-76-9) the short-term toxicity of to freshwater fish was investigated according to OECD 203 under static conditions using Brachydanio rerio as test organism (Lili, 2009). Nominal test concentrations of 100 and 150 mg/L were applied. Test substance monitoring using TOC analysis measured test concentrations of 0.696 and 0.704 mg/L, respectively. Undissolved test material was not removed from the test system; however, this is considered negligible, because no mortality was observed in any treatment and the control throughout the test period of 96 h. Hence, the 96 h-LC50 is determined to be > 0.704 mg/L (arithmetic mean) and thus above the limit of water solubility (< 0.02 mg/L). Additionally, short-term toxicity of fatty acids, C5-9 tetraesters with pentaerythritol (CAS 67762-53-2) to freshwater fish was investigated in a study according to OECD 203 under static conditions using Cyprinus carpio as test organism (Migchielsen, 2012). A nominal test concentration of 100 mg/L (prepared as WAF) was applied. Test substance monitoring measured a concentration of 4.8 mg/L. The final test solution was slightly hazy with a floating layer; however, this is considered negligible, because no mortality was observed in the treatment throughout the test period of 96 h. Hence, the 96 h-LL50 is determined to be > 100 mg/L (nominal) and > 4.8 mg/L (measured) and thus above the limit of water solubility (< 0.006 mg/L, purified water). These results were supported by a study conducted according to EPA OTS 797.1400 investigating the toxicity of fatty acids, C8-10 mixed esters with dipentaerythritol, isooctanoic acid, pentaerythritol and tripentaerythritol (CAS 189200-42-8) on Pimephales promelas (Targia, 1994). No effects were observed up to the highest tested concentration resulting in a LC50 > 5 mg/L after a 96 h exposure period.
Based on these results from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile, it can be concluded that tetraesters from esterification of pentaerythritol with pentanoic, heptanoic and isononanoic acids (former CAS 68424-30-6) will not exhibit short-term toxic effects to freshwater fish up to the limit of water solubility. As it can be seen in the data matrix of the category justification in section 13 and the overall summary, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results; no toxicological effects up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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