Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 451-200-3 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No chronic toxic effects to fish up to the limit of water solubility (< 1 mg/L) is expected, however a further long term toxicity test to aquatic invertebrates for former CAS 68424-30-6 is planned.
Key value for chemical safety assessment
Additional information
The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the long-term toxicity to fish. Thus, in accordance to Annex IX, column 2 no further long-term toxicity testing to fish is proposed.
The available experimental studies on aquatic toxicity for all members of the polyol esters category and in particular those which were chosen as suitable read across all show that on all three trophic levels no acute toxic effects up to the water solubility occur. Furthermore the available data on the long term toxicity of aquatic invertebrates does not reveal adverse effects to daphnids. An experimental study for long-term toxicity to aquatic invertebrates for tetraesters from esterification of pentaerythritol with pentanoic, heptanoic and isononanoic acids (CAS 68424-30-6) is planned. This study together with a 21 day-long-term study with Daphnia magna (Letinski and Bragin, 2012) for decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9), a 15 day-long-term study with Daphnia magna (Low, 1996) for fatty acids, C8-10 (even numbered), di-and triesters with propylidynetrimethanol (CAS.No. 11138-60-6) and a 21 day-long-term study with Daphnia magna (Schlechtriem, 2013) for fatty acids, C16-18 and C18-unsatd., esters with pentaerythritol (CAS-No. 85711-45-1) will provide sufficient evidence for the chronic ecotoxicity of this substance.
Moreover, as there was no sign that fish are the most sensitive species in the short term tests, one can expected that a long-term test with fish will not generate different results than the existing long-term test with Daphnia. Hence due to animal welfare reasons and to avoid unnecessary vertebrate tests, no further long-term test with fish is required for tetraesters from esterification of pentaerythritol with pentanoic, heptanoic and isononanoic acids (CAS 68424-30-6). In addition, due to its ready biodegradability it is not likely that aquatic organisms are exposed to the test substance since it will be ultimately degraded in sewage treatment plants. Therefore, it can be concluded that chronic exposure of this substance to fish is unlikely and that it would not pose a higher risk to fish than it does to daphnids.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
