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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
other: evidence from degradation product
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
European Union Risk Assessment Report - Zinc metal
Author:
Ministry of Housing, Spatial Planning
and the Environment (VROM)
Year:
2008
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Zinc
EC Number:
231-175-3
EC Name:
Zinc
Cas Number:
7440-66-6
Molecular formula:
Zn
IUPAC Name:
zinc
Details on test material:
no information on test material used

Results and discussion

Applicant's summary and conclusion

Executive summary:

Based on the ICDZ data (Cleven et al., 1993) on bioaccumulation of zinc in animals and on

biomagnification (i.e. accumulation and transfer through the food chain), it is concluded that

secondary poisoning is considered to be not relevant in the effect assessment of zinc. Major

decision points for this conclusion are the following. The accumulation of zinc, an essential

element, is regulated in animals of several taxonomic groups, for example in molluscs,

crustaceans, fish and mammals. In mammals, one of the two target species for secondary

poisoning, both the absorption of zinc from the diet and the excretion of zinc, are regulated.

This allows mammals, within certain limits, to maintain their total body zinc level (whole

body homeostasis) and to maintain physiologically required levels of zinc in their various

tissues, both at low and high dietary zinc intakes. The results of field studies, in which

relatively small differences were found in the zinc levels of small mammals from control and

polluted sites, are in accordance with the homeostatic mechanism. These data indicate that the

bioaccumulation potential of zinc in both herbivorous and carnivorous mammals will be low.