Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-527-6 | CAS number: 21679-46-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jusqu'à 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Cobalt and inorganic Cobalt compounds
- Author:
- Kim JH, Gibb HJ, Howe P
- Year:
- 2 006
- Bibliographic source:
- World Health Organization. 88 p.
- Reference Type:
- publication
- Title:
- Acute oral toxicity of inorganic cobalt compounds in rats.
- Author:
- Speijers GJA, Krajnc EI, Berkvens JM, van Logten MJ
- Year:
- 1 982
- Bibliographic source:
- Food and Chemical Toxicology, 20:311–314.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cobalt dichloride
- EC Number:
- 231-589-4
- EC Name:
- Cobalt dichloride
- Cas Number:
- 7646-79-9
- Molecular formula:
- Cl2Co
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- Non disponible
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Non disponible
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Non disponible
- Doses:
- Non disponible
- No. of animals per sex per dose:
- Non disponible
- Control animals:
- not specified
- Details on study design:
- Non disponible
- Statistics:
- Non disponible
Results and discussion
- Preliminary study:
- Pas applicable
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 418 mg/kg bw
- Based on:
- test mat.
- Remarks:
- Basé sur la partie anhydre de la substance
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 190 mg/kg bw
- Based on:
- element
- Remarks:
- Calculé sur la base des masses moléculaires
- Mortality:
- Non disponible
- Clinical signs:
- Non disponible
- Body weight:
- Non disponible
- Gross pathology:
- Non disponible
- Other findings:
- Non disponible
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- La partie inorganique de la substance à enregistrer (Cobalt II) apparait comme nocive (DL50 par voie orale comprise entre 50 et 300 mg/kg de poids corporel) pour les rats Wistar dans les conditions de test utilisées.
- Executive summary:
Du cobalt II (chlorure de cobalt dihydratö) a été administrée à des groupes de rats Wistar mâles et femelles par intubation gastrique. Une DL50 de 418 mg/kg de poids corporel a été établie pour le chlorure de cobalt (anhydre). Ceci correspond à une DL50 de 190 mg/kg de poids corporel pour le cobalt divalent, les calculs étant basés sur les masses moléculaires.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
