Registration Dossier
Registration Dossier
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EC number: 203-483-8 | CAS number: 107-35-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Derek for Windows - Skin Irritation
Derek Nexus 6.0 was released on 12 December 2017.
Derek Nexus is an expert knowledge-based software.
QMRF for this informatic tool is not available. However, this informatic tool is widely used and reported in ECHA Practical Guide - How to use and report (Q)SARs, Version 3.1 (July 2016).
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Derek Nexus 6.0
- Year:
- 2 017
- Bibliographic source:
- Derek Nexus is an expert knowledge-based software.
Materials and methods
- Principles of method if other than guideline:
- Derek for Windows - Skin Irritation
Derek Nexus 6.0 was released on 12 December 2017
QMRF for this informatic tool is not available. However, this informatic tool is widely used and reported in ECHA Practical Guide - How to use and report (Q)SARs, Version 3.1 (July 2016).
The scopes of the structure-activity relationships describing the skin irritation endpoint are defined by the developer to be the applicability domain for the model. Therefore, if a chemical activates an alert describing a structure-activity for skin irritation it can be considered to be within the applicability domain. If a compound does not activate an alert or reasoning rule then Derek makes a negative prediction
Test material
- Reference substance name:
- Taurine
- EC Number:
- 203-483-8
- EC Name:
- Taurine
- Cas Number:
- 107-35-7
- Molecular formula:
- C2H7NO3S
- IUPAC Name:
- 2-aminoethanesulfonic acid
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- The substance to be evaluated is: Taurine - IUPAC name: 2-aminoethanesulfonic acid
C(CS(=O)(=O)O)N
Results and discussion
In vitro
Results
- Remarks on result:
- not measured/tested
In vivo
Results
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The query structure does not match any structural alerts or examples for skin irritation in Derek.
Additionally, the query structure does not contain any alert at the selected reasoning level.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
