2-ethoxy-4-(hydroxymethyl)phenol

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental starting date: 31 July 2016 Experimental completion date: 12 October 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

2-ethoxy-4-(hydroxymethyl)phenol

EC Number:

674-192-5

Cas Number:

4912-58-7

Molecular formula:

C9H12O3

IUPAC Name:

2-ethoxy-4-(hydroxymethyl)phenol

Test material form:

solid: particulate/powder

Specific details on test material used for the study:

Information as provided by the Sponsor. The Certificate of Analysis provided by the Sponsor is presented as.

Identification: EVA
Common name: ETHYLVANILLYL ALCOHOL, White Vanilla
CAS Number: 4912-58-7
CAS Name: Benzenemethanol, 3-ethoxy-4-hydroxy-
Chemical Name: 2- Ethoxy-4-(hydroxymethyl)phenol
Appearance/Physical state: Pale yellow powder
Batch: 4K0001
Purity: 100%
Expiry date: 31 December 2017
Storage conditions: Room temperature in the dark

Results and discussion

Boiling point

Boiling point 1

Key result

Boiling pt.:

ca. 220 °C

Atm. press.:

ca. 101.8 kPa

Decomposition:

yes

Decomp. temp.:

ca. 220 °C

Remarks on result:

other:

Remarks:

Determination 1&2

Boiling point 2

Key result

Boiling pt.:

ca. 493 K

Atm. press.:

ca. 101.8 kPa

Decomposition:

yes

Decomp. temp.:

ca. 493 K

Remarks on result:

other:

Remarks:

Determination 1&2

Boiling point 3

Key result

Boiling pt.:

ca. 220 °C

Atm. press.:

ca. 102.1 kPa

Decomposition:

yes

Decomp. temp.:

ca. 220 °C

Remarks on result:

other:

Remarks:

Determination 3&4

Boiling point 4

Key result

Boiling pt.:

ca. 493 K

Atm. press.:

ca. 102.1 kPa

Decomposition:

yes

Decomp. temp.:

ca. 493 K

Remarks on result:

other:

Remarks:

Determination 3&4

Any other information on results incl. tables

Results

The thermograms and thermographic data for determinations 1 to 4 can be found in the attachment in the section "Attached background material".

Atmospheric pressure:       Determination 1&2: 101.8 kPa

Determination 3&4: 102.1 kPa

Overall result: No boiling temperature before decomposition at approximately 220 °C (493 K).

Discussion

As a result of the initial low rate of enthalpy change during decomposition, the onset temperature could only be approximated.

Similar thermographic profiles were obtained using air and nitrogen atmospheres. This indicated that the decomposition was probably thermal and not oxidative.

The decomposition is based upon the changes in enthalpy shown in the thermograms (small exotherm starting at approximately 220 °C)

Applicant's summary and conclusion

Conclusions:

The test item has been determined to decompose from approximately 220 ± 0.5 °C (493 ± 0.5 K) at approximately at 102.0 kPa. As the test item decomposed, no value for boiling point could be determined.

Executive summary:

The determination was carried out by differential scanning calorimetry, using a procedure designed to be compatible with Method A.2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Conclusion

The test item has been determined to decompose from approximately 220 ± 0.5 °C (493 ± 0.5 K) at approximately at 102.0 kPa. As the test item decomposed, no value for boiling point could be determined.