Dibutyl [[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]succinate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 February 1981 to 04 March 1981

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

no

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Dibutyl [[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]succinate

EC Number:

270-220-1

EC Name:

Dibutyl [[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]succinate

Cas Number:

68413-48-9

Molecular formula:

C28H55O6PS2

IUPAC Name:

1,4-dibutyl 2-({bis[(2-ethylhexyl)oxy](sulfanylidene)-λ⁵-phosphanyl}sulfanyl)butanedioate

Test material form:

liquid

Specific details on test material used for the study:

- Date received: 28 January 1981

Test animals

Species:

rat

Strain:

other: Sherman-Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

- Housing: The animals were housed and maintained in compliance with the U.S. Animal Welfare Act (Pub. L- 94- 279) 9 CFR Part 3.
- Weight: Between 200 and 300 g.
- Feeding / water: The animals were allowed food and water ad libitum, except that they were deprived of food overnight prior to dosing.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

1.0, 2.0, 4.0, 8.0 and 16.0 g/kg

No. of animals per sex per dose:

Five

Control animals:

no

Details on study design:

- 14 day observation period

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

11.3 other: g/kg

Based on:

test mat.

95% CL:

> 7.7 - < 16.7

Mortality:

No mortality was observed in the 1.0, 2.0 and 4.0 g/kg dose groups. One death occurred in the 8.0 g/kg dose group and 4 mortalities were observed in the 16.0 g/kg dose group, where the deaths occurred after 3-4 hours. The sole surviving animal remained in poor health for 3 days before recovering.

Clinical signs:

other: No unusual signs were noted at 1.0, 2.0 and 4.0 g/kg. The 8.0 g/kg, the animals appeared depressed, ruffled and slightly ataxic within 3-4 hours dosing. Animals at 16.0 g/kg were severely depressed, ruffled, dirty, drooling and ataxic within 2 hours after

Gross pathology:

Gross pathologic examination revealed nothing remarkable relating to test material administration.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral of the test material was LD50 of 11300 mg/kg,

Executive summary:

In an acute oral gavage study in male rats performed under conditions similar to the OECD 401 guideline, the LD50 of the test material was 11300 mg/kg.