2-ethoxyethyl ethyl carbonic acid ester

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10 August 2018 to 07 September 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient - Shake Flask Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

gas chromatography

Key result

Type:

Pow

Partition coefficient:

8.54

Temp.:

22 °C

pH:

6.2

Key result

Type:

log Pow

Partition coefficient:

0.928

Temp.:

22 °C

pH:

6.2

- Preliminary Estimate

The estimated partition coefficient was 6.95 at 21.8 ± 0.5 °C, log Pow of 0.84, with a total phase recovery of 101 %. The aqueous phase pH was 6.7.

- Definitive Test

The partition coefficient determined for each flask is shown in the following table:

Table 2: Results

Flask	Organic/aqueous volume ratio	Partition coefficient	Log Pow	Mean partition coefficient
1	2:1	7.77	0.890	7.67
2		7.58	0.880
3	1:1	7.72	0.888	7.84
4		7.96	0.901
5	1:2	9.65	0.985	10.1
6		10.5	1.02

 

Mean Pow : 8.54

Log10 Pow: 0.928

Temperature: 22.0 ± 0.5 °C

- Validation

The linearity of the detector response with respect to concentration for the organic phase analysis was assessed over the nominal concentration range of 5 to 25 mg/L. The results were satisfactory with a correlation coefficient (r) of 1.000 being obtained.

The linearity of the detector response with respect to concentration for the aqueous phase analysis was assessed over the nominal concentration range of 5 to 25 mg/L. The results were satisfactory with a correlation coefficient (r) of 1.000 being obtained.

- Discussion

As the test material had no dissociation constants within the environmentally relevant pH range, the test was performed at an approximately neutral pH.

Due to an interfering peak in the organic matrix blank, the area for this peak was subtracted from the area of the standards and samples prior to calculation of the sample concentrations.

Conclusions:

The partition coefficient of the test material was determined to be 8.54 at 22.0 ± 0.5 °C, and a log10 Pow of 0.928.

Executive summary:

The partition coefficient of the test material was investigated in a study which was conducted in accordance with the standardised guidelines OECD 107 and EU Method A.8, under GLP conditions, following the shake-flask method.

Under the conditions of the study the partition coefficient of the test material was determined to be 8.54 at 22.0 ± 0.5 °C, and a log10 Pow of 0.928.

Description of key information

The partition coefficient of the test material was determined to be 8.54 at 22.0 ± 0.5 °C, and a log10 Pow of 0.928.

Key value for chemical safety assessment

Log Kow (Log Pow):

0.928

at the temperature of:

22 °C

Additional information

The partition coefficient of the test material was investigated in a study which was conducted in accordance with the standardised guidelines OECD 107 and EU Method A.8, under GLP conditions, following the shake-flask method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

Under the conditions of the study the partition coefficient of the test material was determined to be 8.54 at 22.0 ± 0.5 °C, and a log10 Pow of 0.928.